ReviewRheumatology (Oxford, England)2009
Genetics of bone loss in rheumatoid arthritis--role of vitamin D receptor polymorphisms.
Review in Rheumatology (Oxford, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Vitamin D receptor (VDR) gene polymorphism and risk of rheumatoid arthritis (RA): systematic review and meta-analysis.Clinical rheumatology · 2020Pooled it
- Vitamin D receptor FokI, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis : A meta-analysis.Zeitschrift fur Rheumatologie · 2016Pooled it
- Adverse Outcome Pathways Applied to Space Radiation Research.Environmental and molecular mutagenesis · 2025Review
- Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis.Archives of medical science : AMS · 2024Article
- Vitamin D and VDR Gene Polymorphisms' Association with Rheumatoid Arthritis in Lithuanian Population.Medicina (Kaunas, Lithuania) · 2021Article
- Article
- Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response.BioMed research international · 2019Review
- Vitamin D Status and Vitamin D Receptor Gene Polymorphisms Are Associated with Pelvic Floor Disorders in Women.Journal of menopausal medicine · 2018Article
- Inflammation fuels tumor progress and metastasis.Current pharmaceutical design · 2015Review
- Polymorphism in vitamin D receptor and osteoprotegerin genes in Egyptian rheumatoid arthritis patients with and without osteoporosis.Molecular biology reports · 2013Article
- Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women.Molecular biology reports · 2012Article
- The status of serum vitamin D in patients with rheumatoid arthritis and undifferentiated inflammatory arthritis compared with controls.Rheumatology international · 2012Article
- Effects of rituximab treatment on the serum concentrations of vitamin D and interleukins 2, 6, 7, and 10 in patients with rheumatoid arthritis.Biologics : targets & therapy · 2012Article
- Bone mineral density changes in patients with recent-onset rheumatoid arthritis.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2011Article
- VITAMIN D RECEPTOR GENE MUTATIONS AND VITAMIN D SERUM LEVELS IN ASTHMATIC CHILDREN.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloObservational
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
RA is a systemic inflammatory arthritis that leads to local and systemic bone loss. Osteoporosis or the systemic bone loss associated with RA increases the risk for fragility fractures, which can affect quality of life dramatically in RA patients. Although traditional and RA-related risk factors have been defined and studied for osteoporosis associated with RA, genetic factors such as polymorphic variants in the traditional candidate genes for osteoporosis, such as the vitamin D receptor (VDR), type 1 collagen A1 (COLIA1) and oestrogen receptor-alpha (ESR1), have not been well elucidated in RA patients. This review summarizes the currently available literature on the association of VDR polymorphisms with local and systemic bone loss in RA. It also discusses potential targets for genetic research in this area, such as polymorphisms in genes, such as IL-6 (IL6) and TNF receptor type 2 (TNFRSF1B), which control the inflammatory response in RA and may influence bone loss in RA. Defining such genetic factors, in addition to traditional and RA-related risk factors for osteoporosis in RA, may facilitate early identification of patients at high risk for fractures who can then be targeted for treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.