ArticleArteriosclerosis, thrombosis, and vascular biology2009
Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Ischemic stroke is associated with the ABO locus: the EuroCLOT study.Annals of neurology · 2013Pooled it
- Genetic predictors of fibrin D-dimer levels in healthy adults.Circulation · 2011Pooled it
- A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups.Thrombosis research · 2014Article
- Cohort Profile: TwinsUK and healthy ageing twin study.International journal of epidemiology · 2013Article
- Genome scan of clot lysis time and its association with thrombosis in a protein C-deficient kindred.Journal of thrombosis and haemostasis : JTH · 2011Article
- A quantitative trait locus on chromosome 5p influences d-dimer levels in the san antonio family heart study.International journal of vascular medicine · 2010Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveFibrin makes up the structural basis of an occlusive arterial thrombus, and variability in fibrin phenotype relates to cardiovascular risk. The aims of the current study from the EU consortium EuroCLOT were to (1) determine the heritability of fibrin phenotypes and (2) identify QTLs associated with fibrin phenotypes. METHODS AND
results447 dizygotic (DZ) and 460 monozygotic (MZ) pairs of healthy UK white female twins and 199 DZ twin pairs from Denmark were studied. D-dimer, an indicator of fibrin turnover, was measured by ELISA and measures of clot formation, morphology, and lysis were determined by turbidimetric assays. Heritability estimates and genome-wide linkage analysis were performed. Estimates of heritability for d-dimer and turbidometric variables were in the range 17% to 46%, with highest levels for maximal absorbance which provides an estimate of clot density. Genome-wide linkage analysis revealed 6 significant regions with LOD >3 on 5 chromosomes (5, 6, 9, 16, and 17).
conclusionsThe results indicate a significant genetic contribution to variability in fibrin phenotypes and highlight regions in the human genome which warrant further investigation in relation to ischemic cardiovascular disorders and their therapy.
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Registered trials
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