ArticleStroke2009
MRI identification of white matter reorganization enhanced by erythropoietin treatment in a rat model of focal ischemia.
Article in Stroke, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- A systematic review and meta-analysis of erythropoietin in experimental stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2010Pooled it
- Wallerian degeneration in the corticospinal tract evaluated by diffusion tensor imaging correlates with motor deficit 30 days after middle cerebral artery ischemic stroke.AJNR. American journal of neuroradiology · 2010Trial
- Novel proton exchange rate MRI presents unique contrast in brains of ischemic stroke patients.Journal of neuroscience methods · 2020Article
- Post-stroke deficit prediction from lesion and indirect structural and functional disconnection.Brain : a journal of neurology · 2020Article
- Delayed (21 Days) Post Stroke Treatment With RPh201, a Botany-Derived Compound, Improves Neurological Functional Recovery in a Rat Model of Embolic Stroke.Frontiers in neuroscience · 2020Article
- Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke.Theranostics · 2020Article
- Neuroprotection Strategies for Term Encephalopathy.Seminars in pediatric neurology · 2019Review
- Neuroimaging in former preterm children who received erythropoiesis stimulating agents.Pediatric research · 2017Article
- Sensitivity of diffusion MRI to perilesional reactive astrogliosis in focal ischemia.NMR in biomedicine · 2017Article
- The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke.Cell death & disease · 2017Article
- Translational MR Neuroimaging of Stroke and Recovery.Translational stroke research · 2017Review
- Diffusion-Derived Magnetic Resonance Imaging Measures of Longitudinal Microstructural Remodeling Induced by Marrow Stromal Cell Therapy after Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- White matter injury in ischemic stroke.Progress in neurobiology · 2016Review
- Magnetic resonance imaging-based cerebral tissue classification reveals distinct spatiotemporal patterns of changes after stroke in non-human primates.BMC neuroscience · 2015Article
- Neurovascular remodeling in the aged ischemic brain.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Growth factors for the treatment of ischemic brain injury (growth factor treatment).Brain sciences · 2015Review
- Neuroprotective potential of erythropoietin in neonates; design of a randomized trial.Maternal health, neonatology and perinatology · 2015Review
- Attention-network specific alterations of structural connectivity in the undamaged white matter in acute neglect.Human brain mapping · 2014Article
- Erythropoietin signaling promotes oligodendrocyte development following prenatal systemic hypoxic-ischemic brain injury.Pediatric research · 2013Article
- Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives.Frontiers in cellular neuroscience · 2013Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe objectives of the present study were to: (1) noninvasively identify white matter reorganization and monitor its progress within 6 weeks after the onset of stroke; and (2) quantitatively investigate the effect of recombinant human erythropoietin treatment on this structural change using in vivo measurement of diffusion anisotropy.
methodsMale Wistar rats were subjected to middle cerebral artery occlusion and treated with recombinant human erythropoietin intraperitoneally at a dose of 5000 U/kg of body weight (n=11) or the same volume of saline (n=7) daily for 7 days starting 24 hours after middle cerebral artery occlusion. MRI measurements of T2- and diffusion-weighted images and cerebral blood flow were performed and neurological severity score was assessed at 1 day and weekly for 6 weeks after middle cerebral artery occlusion. Luxol fast blue and Bielschowsky staining were used to demonstrate myelin and axons, respectively.
resultsWhite matter reorganization occurred along the ischemic lesion boundary after stroke. The region of white matter reorganization seen on the tissue slice coincided with the elevated area on the fractional anisotropy map, which can be accurately identified. The increase in elevated fractional anisotropy pixels corresponded with progress of white matter reorganization and was associated with improvement of neurological function. Treatment with recombinant human erythropoietin after stroke significantly enhanced white matter reorganization, restored local cerebral blood flow, and expedited functional recovery.
conclusionsWhite matter reorganization can be detected by fractional anisotropy. Elevated fractional anisotropy pixels may be a good MRI index to stage white matter remodeling and predict functional outcome.
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