Trial reportVaccine2009
Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: a randomized controlled trial in Papua New Guinea.
Trial report in Vaccine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00219401 (Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Human Infant Memory B Cell and CD4+ T Cell Responses to HibMenCY-TT Glyco-Conjugate Vaccine.PloS one · 2015Trial
- Safety and immunogenicity of neonatal pneumococcal conjugate vaccination in Papua New Guinean children: a randomised controlled trial.PloS one · 2013Trial
- Pneumococcal conjugate vaccine given shortly after birth stimulates effective antibody concentrations and primes immunological memory for sustained infant protection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Trial
- Pneumococcal conjugate vaccination at birth in a high-risk setting: no evidence for neonatal T-cell tolerance.Vaccine · 2011Trial
- The adaptive immune system in early life: The shift makes it count.Frontiers in immunology · 2022Review
- Ontogeny of cytokine responses to PHA from birth to adulthood.Pediatric research · 2019Observational
- TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.JCI insight · 2017Article
- Cell-Mediated Immunity Against Antigenically Drifted Influenza A(H3N2) Viruses in Children During a Vaccine Mismatch Season.The Journal of infectious diseases · 2016Article
- Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures.Molecular & cellular proteomics : MCP · 2016Article
- Ontogeny of early life immunity.Trends in immunology · 2014Review
- Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines.Pediatric research · 2014Review
- Soluble mediators regulating immunity in early life.Frontiers in immunology · 2014Review
- Reflections on pneumonia in the tropics.Pneumonia (Nathan Qld.) · 2014Review
- The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.PloS one · 2013Article
- Functional deficits of pertussis-specific CD4+ T cells in infants compared to adults following DTaP vaccination.Clinical and experimental immunology · 2012Article
- Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.The Journal of allergy and clinical immunology · 2012Article
- Concomitant administration of Mycobacterium bovis BCG with the meningococcal C conjugate vaccine to neonatal mice enhances antibody response and protective efficacy.Clinical and vaccine immunology : CVI · 2011Article
- Development of newborn and infant vaccines.Science translational medicine · 2011Article
- Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants.PloS one · 2011Article
- 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: neonatal immune function and vaccine responses in children born in low-income versus high-income countries.Clinical and experimental immunology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM(197) compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.