ArticleJournal of theoretical biology2009
A quantitative examination of the role of cargo-exerted forces in axonal transport.
Article in Journal of theoretical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- State of the field: An informatics-based systematic review of the SOD1-G93A amyotrophic lateral sclerosis transgenic mouse model.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2015Pooled it
- Action potential as a contributing factor in axonal transport: a numerical study.Physical and engineering sciences in medicine · 2025Article
- Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.Nature communications · 2025Article
- Article
- Neurofilaments and Neurofilament Proteins in Health and Disease.Cold Spring Harbor perspectives in biology · 2017Review
- Axonal transport cargo motor count versus average transport velocity: is fast versus slow transport really single versus multiple motor transport?Journal of theoretical biology · 2015Article
- Seeking homeostasis: temporal trends in respiration, oxidation, and calcium in SOD1 G93A Amyotrophic Lateral Sclerosis mice.Frontiers in cellular neuroscience · 2015Article
- Neurofilaments are flexible polymers that often fold and unfold, but they move in a fully extended configuration.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Interaction with a kinesin-2 tail propels choline acetyltransferase flow towards synapse.Traffic (Copenhagen, Denmark) · 2012Article
- Cargo distributions differentiate pathological axonal transport impairments.Journal of theoretical biology · 2012Article
- Can molecular motors drive distance measurements in injured neurons?PLoS computational biology · 2009Article
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Authors and funding
2 authors.
Funding
Abstract
Axonal transport, via molecular motors kinesin and dynein, is a critical process in supplying the necessary constituents to maintain normal neuronal function. In this study, we predict the role of cooperativity by motors of the same polarity across the entire spectrum of physiological axonal transport. That is, we examined how the number of motors, either kinesin or dynein, working together to move a cargo, results in the experimentally determined velocity profiles seen in fast and slow anterograde and retrograde transport. We quantified the physiological forces exerted on a motor by a cargo as a function of cargo size, transport velocity, and transport type. Our results show that the force exerted by our base case neurofilament (D(NF)=10 nm, L(NF)=1.6 microm) is approximately 1.25 pN at 600 nm/s; additionally, the force exerted by our base case organelle (D(org)=1 microm) at 1000 nm/s is approximately 5.7 pN. Our results indicate that while a single motor can independently carry an average cargo, cooperativity is required to produce the experimental velocity profiles for fast transport. However, no cooperativity is required to produce the slow transport velocity profiles; thus, a single dynein or kinesin can carry the average neurofilament retrogradely or anterogradely, respectively. The potential role cooperativity may play in the hypothesized mechanisms of motoneuron transport diseases such as amyotrophic lateral sclerosis (ALS) is discussed.
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