SynthesisParasite immunology2009
Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues.
Synthesis in Parasite immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV).PloS one · 2012Pooled it
- Meta-analysis of all immune epitope data in the Flavivirus genus: inventory of current immune epitope data status in the context of virus immunity and immunopathology.Viral immunology · 2010Pooled it
- A comprehensive study of epitopes and immune reactivity among Plasmodium species.BMC microbiology · 2022Article
- Comprehensive Review of HumanFrontiers in immunology · 2019Review
- Article
- Prediction of epitope-based peptides for the utility of vaccine development from fusion and glycoprotein of nipah virus using in silico approach.Advances in bioinformatics · 2014Article
- Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP).Malaria journal · 2013Article
- Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria.Malaria journal · 2013Article
- Article
- T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- A comparison of epitope repertoires associated with myasthenia gravis in humans and nonhuman hosts.Autoimmune diseases · 2012Article
- Peptide binding predictions for HLA DR, DP and DQ molecules.BMC bioinformatics · 2010Article
- Recent advances in B-cell epitope prediction methods.Immunome research · 2010Article
- An integrated approach to epitope analysis II: A system for proteomic-scale prediction of immunological characteristics.Immunome research · 2010Article
- Multiple antigen peptide vaccines against Plasmodium falciparum malaria.Infection and immunity · 2010Article
- Review
- Article
- NIAID workshop on Flavivirus immunity.Viral immunology · 2010Article
- Design and utilization of epitope-based databases and predictive tools.Immunogenetics · 2010Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We present a comprehensive meta-analysis of more than 500 references, describing nearly 5000 unique B cell and T cell epitopes derived from the Plasmodium genus, and detailing thousands of immunological assays. This is the first inventory of epitope data related to malaria-specific immunology, plasmodial pathogenesis, and vaccine performance. The survey included host and pathogen species distribution of epitopes, the number of antibody vs. CD4(+) and CD8(+) T cell epitopes, the genomic distribution of recognized epitopes, variance among epitopes from different parasite strains, and the characterization of protective epitopes and of epitopes associated with parasite evasion of the host immune response. The results identify knowledge gaps and areas for further investigation. This information has relevance to issues, such as the identification of epitopes and antigens associated with protective immunity, the design and development of candidate malaria vaccines, and characterization of immune response to strain polymorphisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.