Evidence map›Paper›PMID 19149517›Full record

ReviewCurrent drug metabolism2009

Vaccines and photodynamic therapies for oral microbial-related diseases.

Pei-Feng Liu, Wen-Hong Zhu, Chun-Ming Huang

Open access · greenAbstract readReview
In one paragraph

Review in Current drug metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Nanotechnology for Dentistry: Prospects and Applications.Nanomaterials (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans.Acta crystallographica. Section F, Structural biology and crystallization communications · 2010
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pei-Feng LiuDivision of Dermatology, Department of Medicine, University of California, San Diego, CA 92161, USA.
Wen-Hong Zhu
Chun-Ming Huang
Discovery Institute · US

Funding

Immunological Secretomes of the Early Anthrax InfectionR01AI067395 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI HUANG, CHUN-MING · 2006 to 2010
$1.2M
Acne Vaccines Targeting a Surface Sialidase and a Secreted CAMP Factor ToxinR41AR056169 · NIAMS · VAXIN INC. · PI HUANG, CHUN-MING · 2008 to 2008
$100k
NIAID NIH HHS R01 AI067395NIAID NIH HHS R01-AI067395-01NIAMS NIH HHS 1R41AR056169-01NIAMS NIH HHS R41 AR056169PHS HHS R21-158002-01PHS HHS R21-R022754-01
6 · The paper itself

Abstract

The mouth is a favorable habitat for a great variety of bacteria. Microbial composition of dental plaque is the usual cause of various oral diseases in humans, including dental caries, periodontal disease and halitosis. In general, oral antibacterial agents such as antibiotics are commonly used to treat oral bacterial infection. Traditional periodontal surgery is painful and time-consuming. In addition, bacterial resistance and toxicity of antibiotics have become a global pandemic and unavoidable. Recently, vaccines for dental caries and periodontal disease have been developed and applied. Moreover, the use of photodynamic therapy has become an alternative to antibiotic drugs. The purpose of this article is to highlight the advantages of vaccine therapy and photodynamic therapy for oral microbial-related diseases compared to treatments with antimicrobial agents and traditional periodontal surgery.

Indexed as

AnimalsAnti-Bacterial AgentsBacterial InfectionsDental CariesDrug Resistance, BacterialHalitosisHumansMouth DiseasesPeriodontal DiseasesPhotochemotherapyVaccinesAnti-Bacterial AgentsVaccines

Identifiers

PMID19149517
PMCPMC2776031
OpenAlexW2113546056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.