ArticleNeurochemical research2009
Wnt/beta-catenin/Tcf signaling pathway activation in malignant progression of rat gliomas induced by transplacental N-ethyl-N-nitrosourea exposure.
Article in Neurochemical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Investigation of dacomitinib on reducing cell necrosis and enhancing cell apoptosis in C6 glioma rat model by MRI.Bioscience reports · 2019Article
- Upregulated RACK1 attenuates gastric cancer cell growth and epithelial-mesenchymal transition via suppressing Wnt/β-catenin signaling.OncoTargets and therapy · 2019Article
- Wnt2 knock down by RNAi inhibits the proliferation of in vitro-cultured human keloid fibroblasts.Medicine · 2018Article
- MEG-3-mediated Wnt/β-catenin signaling pathway controls the inhibition of tunicamycin-mediated viability in glioblastoma.Oncology letters · 2018Article
- Tunicamycin inhibits progression of glioma cells through downregulation of the MEG-3-regulated wnt/β-catenin signaling pathway.Oncology letters · 2018Article
- Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells.Molecular medicine reports · 2018Article
- Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth.Oncotarget · 2016Article
- Downregulation of Pygopus 2 inhibits vascular mimicry in glioma U251 cells by suppressing the canonical Wnt signaling pathway.Oncology letters · 2016Article
- Suppression of wingless-type MMTV integration site family, member 1 expression by small interfering RNA inhibits U251 glioma cell growthOncology letters · 2015Article
- Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.Disease markers · 2015Article
- Nonsteroidal anti-inflammatory drugs diclofenac and celecoxib attenuates Wnt/β-catenin/Tcf signaling pathway in human glioblastoma cells.Neurochemical research · 2013Article
- Current Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible Crosstalk.Genes & cancer · 2013Review
- β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Increased β-catenin/Tcf signaling in pilocytic astrocytomas: a comparative study to distinguish pilocytic astrocytomas from low-grade diffuse astrocytomas.Neurochemical research · 2012Article
- Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.PloS one · 2012Article
- The role of Pygopus 2 in rat glioma cell growth.Medical oncology (Northwood, London, England) · 2011Article
- β-Catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells.Medical oncology (Northwood, London, England) · 2011Article
- HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase.Herpesviridae · 2010Article
- Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth.Journal of neuro-oncology · 2010Article
- Expression and aberrant promoter methylation of Wnt inhibitory factor-1 in human astrocytomas.Journal of experimental & clinical cancer research : CR · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Wnt/beta-catenin/Tcf signaling pathway has been shown to be a crucial factor in the development of many cancers, little is known about its role in glioma malignancy. In the present study, we report the first evidence that Wnt/beta-catenin/Tcf signaling pathway is constitutively activated in experimental gliomas induced by single transplacental dose of N-ethyl-N-nitrosourea (ENU). In the present study we analyzed ENU induced rat gliomas of different stages (P90, P135 and P180) for the expression of beta-catenin, Lef1, Tcf4 and their targets c-Myc, N-Myc and cyclin D1. Western blot analysis revealed upregulation of beta-catenin, Lef1, Tcf4, c-Myc, N-Myc and cyclin D1 in gliomas compared to controls and their levels were progressively increased from initial stage (P90) to progression stage (P180). In consistent with this, immunohistochemistry revealed the cytoplasmic and nuclear accumulation of beta-catenin, and nuclear positivity was evident for Lef1, Tcf4, c-Myc, N-Myc and cyclin D1. Based on these results, we conclude that Wnt/beta-catenin pathway may play a major role in the tumorigenesis and tumor progression in ENU induced rat gliomas.
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