ArticleJournal of bioenergetics and biomembranes2008
Silencing of mitochondrial alternative oxidase gene of Aspergillus fumigatus enhances reactive oxygen species production and killing of the fungus by macrophages.
Article in Journal of bioenergetics and biomembranes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
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- ZipV Is Required for Oxidative Stress Resistance and Pathogenicity inJournal of fungi (Basel, Switzerland) · 2026Article
- The Oxidative Stress Response Highly Depends on Glucose and Iron Availability inJournal of fungi (Basel, Switzerland) · 2024Article
- Comparative mitogenomic analysis ofFrontiers in physiology · 2024Article
- Mitogenome Variations in a Global Population ofJournal of fungi (Basel, Switzerland) · 2023Article
- Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?The Biochemical journal · 2022Review
- The identification of alternative oxidase in intermediate host snails of Schistosoma and its potential role in protecting Oncomelania hupensis against niclosamide-induced stress.Parasites & vectors · 2022Article
- Identification and Functional Characterization of a Putative Alternative Oxidase (Aox) inJournal of fungi (Basel, Switzerland) · 2022Article
- Alternative oxidase gene induced by nitric oxide is involved in the regulation of ROS and enhances the resistance of Pleurotus ostreatus to heat stress.Microbial cell factories · 2021Article
- Respiring to infect: Emerging links between mitochondria, the electron transport chain, and fungal pathogenesis.PLoS pathogens · 2021Review
- Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa.Communications biology · 2020Article
- Known Antimicrobials Versus Nortriptyline inMicroorganisms · 2020Article
- The potential of respiration inhibition as a new approach to combat human fungal pathogens.Current genetics · 2019Review
- Involvement of a G Protein Regulatory Circuit in Alternative Oxidase Production inG3 (Bethesda, Md.) · 2019Article
- Analyses of the three 1-Cys Peroxiredoxins from Aspergillus fumigatus reveal that cytosolic Prx1 is central to HScientific reports · 2018Article
- Identification and Characterization of Key Charged Residues in the Cofilin Protein Involved in Azole Susceptibility, Apoptosis, and Virulence of Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2018Article
- Article
- Insights into the cellular responses to hypoxia in filamentous fungi.Current genetics · 2015Review
- 'Division of labour' in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak.Nature communications · 2014Article
- Humic substances enhance growth and respiration in the basidiomycetes Trametes maxima under carbon limited conditions.Journal of chemical ecology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously demonstrated that conidia from Aspergillus fumigatus incubated with menadione and paraquat increases activity and expression of cyanide-insensitive alternative oxidase (AOX). Here, we employed the RNA silencing technique in A. fumigatus using the vector pALB1/aoxAf in order to down-regulate the aox gene. Positive transformants for aox gene silencing of A. fumigatus were more susceptible both to an imposed in vitro oxidative stress condition and to macrophages killing, suggesting that AOX is required for the A. fumigatus pathogenicity, mainly for the survival of the fungus conidia during host infection and resistance to reactive oxygen species generated by macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.