ArticleMedical microbiology and immunology2009
Seroepidemiological study in a Puumala virus outbreak area in South-East Germany.
Article in Medical microbiology and immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Seroprevalence of hantavirus infection in non-epidemic settings over four decades: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Detection of Puumala hantavirus antigen in human intestine during acute hantavirus infection.PloS one · 2014Trial
- Tropism ofViruses · 2023Article
- Article
- Genetic Diversity ofViruses · 2021Article
- Crimean-Congo hemorrhagic fever virus antibody prevalence in Mauritanian livestock (cattle, goats, sheep and camels) is stratified by the animal's age.PLoS neglected tropical diseases · 2021Article
- Serosurvey of Crimean-Congo Hemorrhagic Fever Virus in Cattle, Mali, West Africa.The American journal of tropical medicine and hygiene · 2017Article
- Puumala hantavirus infections in bank vole populations: host and virus dynamics in Central Europe.BMC ecology · 2017Article
- Validation of the Puumala virus rapid field test for bank voles in Germany.Epidemiology and infection · 2017Article
- Sheep and goats as indicator animals for the circulation of CCHFV in the environment.Experimental & applied acarology · 2016Article
- Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infection.BMC infectious diseases · 2015Article
- Circulation of Crimean-Congo Hemorrhagic Fever Virus in the former Yugoslav Republic of Macedonia revealed by screening of cattle sera using a novel enzyme-linked immunosorbent assay.PLoS neglected tropical diseases · 2015Article
- Identification of factors influencing the Puumala virus seroprevalence within its reservoir in aMontane Forest Environment.Viruses · 2014Article
- Development of an immunochromatography strip test based on truncated nucleocapsid antigens of three representative hantaviruses.Virology journal · 2014Article
- Seroprevalence study in forestry workers from eastern Germany using novel genotype 3- and rat hepatitis E virus-specific immunoglobulin G ELISAs.Medical microbiology and immunology · 2012Article
- Recent publications in medical microbiology and immunology: a retrospective.Medical microbiology and immunology · 2012Review
- In Search for Factors that Drive Hantavirus Epidemics.Frontiers in physiology · 2012Article
- Seroprevalence study in forestry workers of a non-endemic region in eastern Germany reveals infections by Tula and Dobrava-Belgrade hantaviruses.Medical microbiology and immunology · 2011Article
- Phylogenetic analysis of Puumala virus subtype Bavaria, characterization and diagnostic use of its recombinant nucleocapsid protein.Virus genes · 2011Article
- Characterization of monoclonal antibodies against hantavirus nucleocapsid protein and their use for immunohistochemistry on rodent and human samples.Archives of virology · 2011Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puumala virus (PUUV) is the cause of the majority of haemorrhagic fever with renal syndrome cases in Germany. In 2004, a nephropathia epidemica outbreak was recorded in Lower Bavaria, South-East Germany. For a seroepidemiological study in this region including the resident population at four locations (n = 178) and soldiers from one location (n = 208) indirect immunoglobulin M (IgM) and immunoglobulin G (IgG) enzyme-linked immunosorbent assays (ELISAs) and immunoblot tests based on a yeast-expressed PUUV nucleocapsid protein were established. The validation using human serum panels originating from Germany revealed a diagnostic sensitivity and specificity of 98/100% for the IgM ELISA, 99/99% for the IgG ELISA, 99/100% for the IgM immunoblot test and 100/96% for the IgG immunoblot test. Using the novel IgG assays as well as a commercial IgG ELISA and an immunofluorescence assay for the resident population an average prevalence of 6.7% (12 of 178) with a range of 0% (0 of 21) to 11.9% (7 of 59) was observed. Positive serological results were equally distributed between males and females with an average age of 63 for males and 52 for females. The seroprevalence in the soldier group was found to be about 1% with one positive male of 203 (age 46 years) and one positive female of five (age 47 years). In conclusion, the PUUV seroprevalence in the residents of the outbreak region in Lower Bavaria was found to be up to fivefold higher than the average hantavirus seroprevalence of the German population.
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