ArticlePLoS pathogens2009
Imbalanced lignin biosynthesis promotes the sexual reproduction of homothallic oomycete pathogens.
Article in PLoS pathogens, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 102 citations in OpenAlex.
- PsWRKY75 orchestrates lignin biosynthesis and H₂O₂ metabolism to modulate disease resistance: a physiological and biochemical mechanism in Prunus sibirica L.BMC plant biology · 2026Article
- From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Overexpression of OsCCR1, OsCOMT5, OsCAD2 and OsCCoAOMT1 Genes Enhances Lignin Accumulation and Confers Tolerance Against Rhizoctonia solani in Rice (Oryza sativa).Molecular biotechnology · 2026Article
- Enhancing maize resistance to Fusarium verticillioides through modulation of cell wall structure and components by ZmXYXT2.Journal of advanced research · 2025Article
- BvHP4b gene in red beet promotes tuber enlargement and enhances resistance to Pst DC3000.BMC genomics · 2025Article
- A dual-subcellular localized β-glucosidase confers pathogen and insect resistance without a yield penalty in maize.Plant biotechnology journal · 2024Article
- Comparative transcriptome analysis reveals the importance of phenylpropanoid biosynthesis for the induced resistance of 84K poplar to anthracnose.BMC genomics · 2024Article
- A fungal endophyte induces local cell wall-mediated resistance in wheat roots against take-all disease.Frontiers in plant science · 2024Article
- VAMP726 from maize and Arabidopsis confers pollen resistance to heat and UV radiation by influencing lignin content of sporopollenin.Plant communications · 2023Article
- Identification of High Tolerance to Jujube Witches' Broom in Indian Jujube (Plants (Basel, Switzerland) · 2023Article
- Plant Cell Wall Integrity Perturbations and Priming for Defense.Plants (Basel, Switzerland) · 2022Review
- Ocimum sanctum, OscWRKY1, regulates phenylpropanoid pathway genes and promotes resistance to pathogen infection in Arabidopsis.Plant molecular biology · 2022Article
- Specific interaction of an RNA-binding protein with the 3'-UTR of its target mRNA is critical to oomycete sexual reproduction.PLoS pathogens · 2021Article
- Assessment of the Role of PAL in Lignin Accumulation in Wheat (International journal of molecular sciences · 2021Article
- Article
- Maize nicotinate N-methyltransferase interacts with the NLR protein Rp1-D21 and modulates the hypersensitive response.Molecular plant pathology · 2021Article
- GhMYB4 downregulates lignin biosynthesis and enhances cotton resistance to Verticillium dahliae.Plant cell reports · 2021Article
- Phenylpropanoid Pathway Engineering: An Emerging Approach towards Plant Defense.Pathogens (Basel, Switzerland) · 2020Review
- Lignin-based barrier restricts pathogens to the infection site and confers resistance in plants.The EMBO journal · 2019Article
- The cotton laccase gene GhLAC15 enhances Verticillium wilt resistance via an increase in defence-induced lignification and lignin components in the cell walls of plants.Molecular plant pathology · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lignin is incorporated into plant cell walls to maintain plant architecture and to ensure long-distance water transport. Lignin composition affects the industrial value of plant material for forage, wood and paper production, and biofuel technologies. Industrial demands have resulted in an increase in the use of genetic engineering to modify lignified plant cell wall composition. However, the interaction of the resulting plants with the environment must be analyzed carefully to ensure that there are no undesirable side effects of lignin modification. We show here that Arabidopsis thaliana mutants with impaired 5-hydroxyguaiacyl O-methyltransferase (known as caffeate O-methyltransferase; COMT) function were more susceptible to various bacterial and fungal pathogens. Unexpectedly, asexual sporulation of the downy mildew pathogen, Hyaloperonospora arabidopsidis, was impaired on these mutants. Enhanced resistance to downy mildew was not correlated with increased plant defense responses in comt1 mutants but coincided with a higher frequency of oomycete sexual reproduction within mutant tissues. Comt1 mutants but not wild-type Arabidopsis accumulated soluble 2-O-5-hydroxyferuloyl-L-malate. The compound weakened mycelium vigor and promoted sexual oomycete reproduction when applied to a homothallic oomycete in vitro. These findings suggested that the accumulation of 2-O-5-hydroxyferuloyl-L-malate accounted for the observed comt1 mutant phenotypes during the interaction with H. arabidopsidis. Taken together, our study shows that an artificial downregulation of COMT can drastically alter the interaction of a plant with the biotic environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.