Evidence map›Paper›PMID 19148180›Full record

ReviewNature reviews. Microbiology2009

Apoptosis in animal models of virus-induced disease.

Penny Clarke, Kenneth L Tyler

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Infection and immunity · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Programmed Necrosis in Host Defense.Current topics in microbiology and immunology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Penny ClarkeDepartment of Neurology, University of Colorado, Denver Health Sciences Programs, Anschutz Medical Campus, Aurora, Colorado 80045, USA. Penny.Clarke@uchsc.edu
Kenneth L Tyler

Funding

Mechanisms of Apoptosis in the central nervous systemR01NS050138 · NINDS · UNIVERSITY OF COLORADO DENVER · PI TYLER, KENNETH L. · 2005 to 2009
$1.3M
Molecular Basis of Microbial PathogenesisT32AI007537 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOLMES, RANDALL K · 1998 to 2007
$1.3M
Mechanisms of virus-induced apoptosis in neurons and CNSR01NS051403 · NINDS · UNIVERSITY OF COLORADO DENVER · PI TYLER, KENNETH L. · 2006 to 2010
$1.2M
NIAID NIH HHS T32 AI007537NIAID NIH HHS T32AI07537NINDS NIH HHS 1R01NS051403NINDS NIH HHS 5R01NS050138NINDS NIH HHS R01 NS050138NINDS NIH HHS R01 NS051403
6 · The paper itself

Abstract

Apoptosis is associated with virus-induced human diseases of the central nervous system, heart and liver, and causes substantial morbidity and mortality. Although virus-induced apoptosis is well characterized in individual cells in cell culture, virus-induced apoptosis in vivo and the role of apoptosis in virus-induced disease is not well established. This review focuses on animal models of virus-induced diseases of the central nervous system, heart and liver that provide insights into the role of apoptosis in pathogenesis, the pathways involved and the potential therapeutic implications.

Indexed as

AnimalsApoptosisCaspasesDisease Models, AnimalHumansMiceRatsVirus DiseasesCaspases

Identifiers

PMID19148180
PMCPMC2772826

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.