SynthesisJournal of perinatology : official journal of the California Perinatal Association2009
Early interventions involving parents to improve neurodevelopmental outcomes of premature infants: a meta-analysis.
Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Home visits following hospital discharge for families with preterm and low-birthweight infants.The Cochrane database of systematic reviews · 2026Pooled it
- Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.The Cochrane database of systematic reviews · 2024Pooled it
- Positive Parenting and Early Childhood Cognition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Clinical child and family psychology review · 2023Pooled it
- Effectiveness of interventions on early neurodevelopment of preterm infants: a systematic review and meta-analysis.BMC pediatrics · 2021Pooled it
- Social-environmental moderators of neurodevelopmental outcomes in youth born preterm: A systematic review.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Pooled it
- Effect of neonatal therapy on the motor, cognitive, and behavioral development of infants born preterm: a systematic review.Developmental medicine and child neurology · 2020Pooled it
- Do NICU developmental care improve cognitive and motor outcomes for preterm infants? A systematic review and meta-analysis.BMC pediatrics · 2020Pooled it
- Effectiveness of early intervention programs for parents of preterm infants: a meta-review of systematic reviews.BMC pediatrics · 2018Pooled it
- Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.The Cochrane database of systematic reviews · 2015Pooled it
- Key components of early intervention programs for preterm infants and their parents: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2013Pooled it
- Public health interventions in midwifery: a systematic review of systematic reviews.BMC public health · 2012Pooled it
- Neurodevelopmental outcome at 5 to 6 years of age of an early intervention program in preterm infants.Scientific reports · 2025Trial
- Moderate-To-Late Preterm Infants Benefit From the Early Collaborative Intervention: Primary Outcomes of an RCT.Acta paediatrica (Oslo, Norway : 1992) · 2025Trial
- 'I Did Not Know We Could Exercise This Small Premature Baby': Challenges Experienced by Parents While Implementing Early Intervention for Their Preterm Infants-A Qualitative Perspective.Child: care, health and development · 2025Trial
- Trial
- Early developmental support for preterm infants based on exploratory behaviors: A parallel randomized controlled study.Brain and behavior · 2023Trial
- Trial
- Early skin-to-skin contact or incubator for very preterm infants: study protocol for a randomized controlled trial.Trials · 2016Trial
- The effectiveness of video interaction guidance in parents of premature infants: a multicenter randomised controlled trial.BMC pediatrics · 2012Trial
- Family nurture intervention (FNI): methods and treatment protocol of a randomized controlled trial in the NICU.BMC pediatrics · 2012Trial
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine in a systematic review, whether interventions for infant development that involve parents, improve neurodevelopment at 12 months corrected age or older. STUDY
designRandomized trials were identified where an infant intervention was aimed to improve development and involved parents of preterms; and long-term neurodevelopment using standardized tests at 12 months (or longer) was reported.
resultIdentified studies (n=25) used a variety of interventions including parent education, infant stimulation, home visits or individualized developmental care. Meta-analysis at 12 months (N=2198 infants) found significantly higher mental (N=2198) and physical (N=1319) performance scores favoring the intervention group. At 24 months, the mental (N=1490) performance scores were improved, but physical (N=1025) performance scores were not statistically significant. The improvement in neurodevelopmental outcome was not sustained at 36 months (N=961) and 5 years (N=1017).
conclusionPositive clinically meaningful effects (>5 points) are seen to an age of 36 months, but are no longer present at 5 years.
Indexed as
Identifiers
19148113What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.