ReviewJournal of genetics2008
Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters.
Review in Journal of genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 85 citations in OpenAlex.
- Article
- The Change Rate of theBiology · 2024Article
- Treatment of Circadian Rhythm Sleep-Wake Disorders.Current neuropharmacology · 2022Review
- Relationship between Auditory Evoked Potentials and Circadian Preference in Patients with Major Depressive Episodes.Brain sciences · 2020Article
- The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction.Pathogens (Basel, Switzerland) · 2020Review
- Review
- Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health.Advances in nutrition (Bethesda, Md.) · 2019Review
- Dad's Snoring May Have Left Molecular Scars in Your DNA: the Emerging Role of Epigenetics in Sleep Disorders.Molecular neurobiology · 2018Review
- Sleep Deprivation and the Epigenome.Frontiers in neural circuits · 2018Review
- The genomic landscape of human cellular circadian variation points to a novel role for the signalosome.eLife · 2017Article
- CLOCK 3111 T/C SNP interacts with emotional eating behavior for weight-loss in a Mediterranean population.PloS one · 2014Article
- Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- The effect of different photoperiods in circadian rhythms of per3 knockout mice.BioMed research international · 2014Article
- Diversity of human clock genotypes and consequences.Progress in molecular biology and translational science · 2013Review
- The role of sleep problems and circadian clock genes in childhood psychiatric disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
- Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability.Translational psychiatry · 2012Article
- Divergent roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillators.PloS one · 2012Article
- Advancing the biobehavioral research of fatigue with genetics and genomics.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2011Article
- Article
- Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythms and sleep are two separate but intimately related processes. Circadian rhythms are generated through the precisely controlled, cyclic expression of a number of genes designated clock genes. Genetic variability in these genes has been associated with a number of phenotypic differences in circadian as well as sleep parameters, both in mouse models and in humans. Diurnal preferences as determined by the selfreported Horne-Ostberg (HO) questionnaire, has been associated with polymorphisms in the human genes CLOCK, PER1, PER2 and PER3. Circadian rhythm-related sleep disorders have also been associated with mutations and polymorphisms in clock genes, with the advanced type cosegrating in an autosomal dominant inheritance pattern with mutations in the genes PER2 and CSNK1D, and the delayed type associating without discernible Mendelian inheritance with polymorphisms in CLOCK and PER3. Several mouse models of clock gene null alleles have been demonstrated to have affected sleep homeostasis. Recent findings have shown that the variable number tandem polymorphism in PER3, previously linked to diurnal preference, has profound effects on sleep homeostasis and cognitive performance following sleep loss, confirming the close association between the processes of circadian rhythms and sleep at the genetic level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.