ArticleThe American journal of pathology2009
Mechanistic effects of long-term ultraviolet B irradiation induce epidermal and dermal changes in human skin xenografts.
Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Current and emerging new approach & methodologies for skin hazard assessment.Toxicological research · 2026Review
- Establishment of a BALB/c Mouse Model for Photoaged Skin: Insights into UV-Induced Dermatological Changes.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Article
- Stem cell-derived extracellular vesicles for high-altitude skin injuries: pathological mechanisms, advanced Nano-delivery, and translational perspectives.Frontiers in bioengineering and biotechnology · 2026Review
- Oral Administration of Edible Snail Extract Powder Prevents UVB-Induced Skin Damage.Food science & nutrition · 2025Article
- Article
- Lactic Acid Bacteria Improve the Photoprotective Effect via MAPK/AP-1/MMP Signaling Pathway on Skin Fibroblasts.Microorganisms · 2022Article
- Protective Effect ofMicroorganisms · 2022Article
- UV-induced reduction in Polycomb repression promotes epidermal pigmentation.Developmental cell · 2021Article
- Caviar Extract and Its Constituent DHA Inhibits UVB-Irradiated Skin Aging by Inducing Adiponectin Production.International journal of molecular sciences · 2020Article
- UVA Photoprotective Activity of Brown MacroalgaeBiomedicines · 2019Article
- Comparative Measurement of Biophysical Parameters in Consideration of Skin Graft Donor Site for Nasal Defects.Annals of dermatology · 2019Article
- Skin aging as a mechanical phenomenon: The main weak links.Nutrition and healthy aging · 2018Article
- Recovery of extracellular matrix components by enalapril maleate during the repair process of ultraviolet B-induced wrinkles in mouse skin.Biochemistry and biophysics reports · 2015Article
- Modifications in stromal extracellular matrix of aged corneas can be induced by ultraviolet A irradiation.Aging cell · 2015Article
- Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis.The American journal of pathology · 2011Article
- Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection.Scientific reports · 2011Article
- In vivo assessment of acute UVB responses in normal and Xeroderma Pigmentosum (XP-C) skin-humanized mouse models.The American journal of pathology · 2010Article
- Sun-induced changes in stratum corneum function are gender and dose dependent in a Chinese population.Skin pharmacology and physiology · 2010Article
- The translational basis of human cutaneous photoaging: on models, methods, and meaning.The American journal of pathology · 2009Review
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
UVB irradiation has been reported to induce photoaging and suppress systemic immune function that could lead to photocarcinogenesis. However, because of the paucity of an UVB-induced photodamaged skin model, precise and temporal mechanism(s) underlying the deleterious effects of long-term UVB exposure on human skin have yet to be delineated. In this study, we established a model using human skin xenografted onto severe combined immunodeficient mice, which were subsequently challenged by repeated UVB irradiation for 6 weeks. Three-dimensional optical image analysis of skin replicas and noninvasive biophysical measurements illustrated a significant increase in skin surface roughness, similar to premature photoaging, and a significant loss of skin elasticity after long-term UVB exposure. Resembling authentically aged skin, UVB-exposed samples exhibited significant increases in epithelial keratins (K6, K16, K17), elastins, and matrix metalloproteinases (MMP-1, MMP-9, MMP-12) as well as degradation of collagens (I, IV, VII). The UVB-induced deterioration of fibrous keratin intermediate filaments was also observed in the stratum corneum. Additionally, similarities in gene expression patterns between our model and chronologically aged skin substantiated the plausible relationship between photodamage and chronological age. Furthermore, severe skin photodamage was observed when neutralizing antibodies against TIMP-1, an endogenous inhibitor of MMPs, were administered during the UVB exposure regimen. Taken together, these findings suggest that our skin xenograft model recapitulates premature photoaged skin and provides a comprehensive tool with which to assess the deleterious effects of UVB irradiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.