ArticleThe American journal of pathology2009
Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling.
Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Review
- Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts?Biomedicines · 2022Review
- Tissue distribution of stem cell factor in adults.Experimental and molecular pathology · 2021Article
- Inhibition of the stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- A review of inflammatory mechanism in airway diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2.Cell communication and signaling : CCS · 2018Article
- Association of stem cell factor gene expression with severity and atopic state in patients with bronchial asthma.Respiratory research · 2017Article
- Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction.The Journal of experimental medicine · 2016Article
- Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes.Diabetes · 2015Article
- Mesenchymal stem cells regulate airway contractile tissue remodeling in murine experimental asthma.Allergy · 2014Article
- The in vivo fibrotic role of FIZZ1 in pulmonary fibrosis.PloS one · 2014Article
- Serum cytokine profiling and enrichment analysis reveal the involvement of immunological and inflammatory pathways in stable patients with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2014Article
- Hematopoietic stem and progenitor cells in inflammation and allergy.Frontiers in immunology · 2013Review
- Essential role of stem cell factor-c-Kit signalling pathway in bleomycin-induced pulmonary fibrosis.The Journal of pathology · 2013Article
- Different healing process of esophageal large mucosal defects by endoscopic mucosal dissection between with and without steroid injection in an animal model.BMC gastroenterology · 2013Article
- Are mast cells instrumental for fibrotic diseases?Frontiers in pharmacology · 2013Review
- Implication for bone marrow derived stem cells in hepatocyte regeneration after orthotopic liver transplantation.International journal of hepatology · 2013Review
- Bone marrow progenitor cells do not contribute to liver fibrogenic cells.World journal of hepatology · 2012Article
- Genesis of the myofibroblast in lung injury and fibrosis.Proceedings of the American Thoracic Society · 2012Review
- Resident tissue-specific mesenchymal progenitor cells contribute to fibrogenesis in human lung allografts.The American journal of pathology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence suggests that bone marrow-derived fibroblasts are involved in airway remodeling in asthma, but the role and mechanism of recruitment of these fibroblasts remains unclear. Stem cell factor (SCF), a key factor in the propagation of hematopoietic stem cells, is important in the process of airway remodeling as well. To test the hypothesis that SCF is involved in the recruitment and differentiation of bone marrow-derived progenitor cells, GFP-bone marrow chimeric mice were created. These mice were then sensitized and chronically challenged with cockroach antigen to induce chronic airway disease. Fluorescence microscopy revealed an influx of significant numbers of GFP-expressing fibroblasts in the airways of these mice, which was confirmed by flow cytometric analysis of cells co-expressing both GFP and collagen I. These cells preferentially expressed c-kit, interleukin-31 receptor, and telomerase reverse transcriptase when compared with control lung-derived fibroblasts. Interestingly, SCF stimulated interleukin-31 receptor expression in bone marrow cells, whereas interleukin-31 strongly induced telomerase reverse transcriptase expression in fibroblasts. Treatment with neutralizing antibodies to SCF significantly reduced airway remodeling and suppressed the recruitment of these bone marrow-derived cells to the lung. Thus SCF in conjunction with interleukin-31 may play a significant role in airway remodeling by promoting the recruitment of bone marrow-derived fibroblast precursors into the lung with the capacity to promote lung myofibroblast differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.