ReviewAlcohol and alcoholism (Oxford, Oxfordshire)
Foetal Alcohol Spectrum Disorders and alterations in brain and behaviour.
Review in Alcohol and alcoholism (Oxford, Oxfordshire). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 5 syntheses or guidelines pooled it, 356 citations in OpenAlex.
- Cognitive and Behavioural Attention in Children with Low-Moderate and Heavy Doses of Prenatal Alcohol Exposure: a Systematic Review and Meta-analysis.Neuropsychology review · 2021Pooled it
- A Systematic Review of the Effects of Perinatal Alcohol Exposure and Perinatal Marijuana Exposure on Adult Neurogenesis in the Dentate Gyrus.Alcoholism, clinical and experimental research · 2020Pooled it
- White matter microstructure in fetal alcohol spectrum disorders: A systematic review of diffusion tensor imaging studies.Human brain mapping · 2019Pooled it
- Meta-Analysis of Gene Expression Patterns in Animal Models of Prenatal Alcohol Exposure Suggests Role for Protein Synthesis Inhibition and Chromatin Remodeling.Alcoholism, clinical and experimental research · 2016Pooled it
- Executive Functioning in Children and Adolescents Prenatally Exposed to Alcohol: A Meta-Analytic Review.Neuropsychology review · 2015Pooled it
- Persistent dose-dependent changes in brain structure in young adults with low-to-moderate alcohol exposure in utero.Alcoholism, clinical and experimental research · 2012Trial
- Brief intervention to reduce risky drinking in pregnancy: study protocol for a randomized controlled trial.Trials · 2012Trial
- Article
- The developmental-diagnostic gap: cultural invisibility and delayed recognition of prenatal alcohol exposure.Frontiers in psychology · 2026Review
- Early biomarkers associated with prenatal alcohol exposure and neurodevelopmental outcomes.Frontiers in pharmacology · 2026Review
- Investigating the Impact of Chronical Prenatal Alcohol Exposure on Fetal Vascular Development Across Pregnancy Stages Using Photoacoustic Tomography.Journal of biophotonics · 2025Article
- Transgenerational of Oxidative Damage Induced by Prenatal Ethanol Exposure on Spatial Learning/Memory and BDNF in the of Male Rats.IBRO neuroscience reports · 2024Article
- Longitudinal effects of prenatal substance use and environmental stressors on executive functioning in low-income African American adolescents: A latent growth modeling analysis.Brain and cognition · 2024Article
- Sex as a Determinant of Age-Related Changes in the Brain.International journal of molecular sciences · 2024Review
- Article
- Review
- Prenatal exposure to alcohol impairs responses of cerebral arterioles to activation of potassium channels: Role of oxidative stress.Alcohol, clinical & experimental research · 2023Article
- Neurotoxicology of alcohol: a bibliometric and science mapping analysis.Frontiers in pharmacology · 2023Article
- Effects of genetics and sex on adolescent behaviors following neonatal ethanol exposure in BXD recombinant inbred strains.Frontiers in neuroscience · 2023Article
- Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring.Frontiers in neuroscience · 2023Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The term 'Foetal Alcohol Spectrum Disorders (FASD)' refers to the range of disabilities that may result from prenatal alcohol exposure. This article reviews the effects of ethanol on the developing brain and its long-term structural and neurobehavioural consequences. Brain imaging, neurobehavioural and experimental studies demonstrate the devastating consequences of prenatal alcohol exposure on the developing central nervous system (CNS), identifying specific brain regions affected, the range of severity of effects and mechanisms involved. In particular, neuroimaging studies have demonstrated overall and regional volumetric and surface area reductions, abnormalities in the shape of particular brain regions, and reduced and increased densities for white and grey matter, respectively. Neurobehaviourally, FASD consists of a continuum of long-lasting deficits affecting multiple aspects of cognition and behaviour. Experimental studies have also provided evidence of the vulnerability of the CNS to the teratogenic effects of ethanol and have provided new insight on the influence of risk factors in the type and severity of observed brain abnormalities. Finally, the potential molecular mechanisms that underlie the neuroteratological effects of alcohol are discussed, with particular emphasis on the role of glial cells in long-term neurodevelopmental liabilities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.