ArticleClinical cancer research : an official journal of the American Association for Cancer Research2009
DNA repair gene polymorphisms and risk of pancreatic cancer.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 13 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 13 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Pooled it
- Genetic polymorphisms and pancreatic cancer risk: A PRISMA-compliant systematic review and meta-analysis.Medicine · 2019Pooled it
- Association between ATM rs1801516 polymorphism and cancer susceptibility: a meta-analysis involving 12,879 cases and 18,054 controls.BMC cancer · 2018Pooled it
- Association between ATM gene polymorphisms, lung cancer susceptibility and radiation-induced pneumonitis: a meta-analysis.BMC pulmonary medicine · 2017Pooled it
- Human 8-oxoguanine DNA glycosylase gene polymorphism (Ser326Cys) and cancer risk: updated meta-analysis.Oncotarget · 2017Pooled it
- Pooled it
- A systematic review and meta-analysis of the association between OGG1 Ser326Cys polymorphism and cancers.Medical oncology (Northwood, London, England) · 2015Pooled it
- The hOGG1 Ser326Cys polymorphism contributes to digestive system cancer susceptibility: evidence from 48 case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Relevance of LIG4 gene polymorphisms with cancer susceptibility: evidence from a meta-analysis.Scientific reports · 2014Pooled it
- Association of OGG1 Ser326Cys polymorphism and pancreatic cancer susceptibility: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association between ATM polymorphisms and cancer risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- Pooled it
- The effect of hOGG1 Ser326Cys polymorphism on cancer risk: evidence from a meta-analysis.PloS one · 2011Pooled it
- <p>Unveiling sex differences in pancreatic ductal adenocarcinoma: Current evidence and future directions (Review)</p>.International journal of oncology · 2026Review
- Structural pharmacogenomics of drug-associated SNPs in oral squamous cell carcinoma.Frontiers in genetics · 2026Article
- Methylome-wide association study of multidimensional resilience.Development and psychopathology · 2025Article
- Novel CandidateCancers · 2023Article
- Acetylation and Deacetylation of DNA Repair Proteins in Cancers.Frontiers in oncology · 2020Review
- p53 protein expression affected by TP53 polymorphism is associated with the biological behavior and prognosis of low rectal cancer.Oncology letters · 2019Article
- Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma.Familial cancer · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe current research was undertaken to examine the association between genetic variations in DNA repair and pancreatic cancer risk. EXPERIMENTAL
designWe analyzed 9 single nucleotide polymorphisms of 7 DNA repair genes (LIG3, LIG4, OGG1, ATM, POLB, RAD54L, and RECQL) in 734 patients with pancreatic adenocarcinoma and 780 healthy controls using the Taqman method. Information on cigarette smoking, alcohol consumption, medical history, and other risk factors was collected by personal interview.
resultsThe homozygous mutant genotype of LIG3 G-39A [odds ratio (OR), 0.23; 95% confidence interval (CI), 0.06-0.82; P = 0.027] and ATM D1853N (OR, 2.55; 95% CI, 1.08-6.00; P = 0.032) was significantly associated with altered risk for pancreatic cancer. A statistically significant interaction of ATM D1853N and LIG4 C54T genotype with diabetes on the risk of pancreatic cancer was also detected. Compared with nondiabetics with the ATM D1853N GG genotype, nondiabetics with the GA/AA, diabetics with the GG, and diabetics with the GA/AA genotypes, respectively, had ORs (95% CI) of 0.96 (0.74-1.24), 1.32 (0.89-1.95), and 3.23 (1.47-7.12; P(interaction) = 0.032, likelihood ratio test). The OR (95% CI) was 0.91 (0.71-1.17), 1.11 (0.73-1.69), and 2.44 (1.34-4.46) for nondiabetics carrying the LIG4 CT/TT genotype, diabetics with the CC genotype, and diabetics carrying the CT/TT genotype, respectively, compared with nondiabetics carrying the CC genotype (P(interaction) = 0.02).
conclusionsThese observations suggest that genetic variations in DNA repair may act alone or in concert with other risk factors on modifying a patient's risk for pancreatic cancer.
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