C-reactive protein and memory function suggest antagonistic pleiotropy in very old nondemented subjects.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

24 citing papers in PubMed.

1. Change in inflammatory markers and cognitive status in the oldest-old women from the Study of Osteoporotic Fractures.Journal of the American Geriatrics Society · 2014
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2. Telomere length and cognitive changes in 7,877 older UK adults of European ancestry.Frontiers in aging · 2024
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3. High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study.Brain sciences · 2023
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4. Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer's disease.Frontiers in aging neuroscience · 2023
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5. Limited evidence of a shared genetic relationship between C-reactive protein levels and cognitive function in older UK adults of European ancestry.Frontiers in dementia · 2023
   Article
6. Understanding the Physiological Links Between Physical Frailty and Cognitive Decline.Aging and disease · 2020
   Review
7. C-reactive protein and risk of cognitive decline: The REGARDS study.PloS one · 2020
   Article
8. Associations of hemoglobin A1c with cognition reduced for long diabetes duration.Alzheimer's & dementia (New York, N. Y.) · 2019
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9. The protected survivor model: Using resistant successful cognitive aging to identify protection in the very old.Medical hypotheses · 2018
   Article
10. Repeated systemic inflammation was associated with cognitive deficits in older Britons.Alzheimer's & dementia (Amsterdam, Netherlands) · 2016
    Article
11. Cognitive Ageing in Great Britain in the New Century: Cohort Differences in Episodic Memory.PloS one · 2015
    Article
12. C-reactive protein, APOE genotype and longitudinal cognitive change in an older population.Age and ageing · 2014
    Article
13. Epigenetic determinants of healthy and diseased brain aging and cognition.JAMA neurology · 2013
    Review
14. Frailty in elderly people.Lancet (London, England) · 2013
    Review
15. How predictive of dementia are peripheral inflammatory markers in the elderly?Neurodegenerative disease management · 2012
    Article
16. C-reactive protein and familial risk for dementia: a phenotype for successful cognitive aging.Neurology · 2012
    Article
17. Synaptic protein deficits are associated with dementia irrespective of extreme old age.Neurobiology of aging · 2012
    Article
18. Haemoglobin A(1c) and cognitive function in very old, cognitively intact men.Age and ageing · 2012
    Article
19. Homocysteine and cognitive function in very elderly nondemented subjects.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2011
    Article
20. Is C-reactive protein level a marker of advanced motor and neuropsychiatric complications in Parkinson's disease?Journal of neural transmission (Vienna, Austria : 1996) · 2011
    Article

Corrections and comments

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Authors and funding

10 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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