ArticleEndocrinology2009
Developmental profiles of neuroendocrine gene expression in the preoptic area of male rats.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Neural Circuitry Involving Substance P in Male Sexual Behavior.Neuroscience bulletin · 2024Article
- Key role of estrogen receptor β in the organization of brain and behavior of the Japanese quail.Hormones and behavior · 2020Article
- Social and neuromolecular phenotypes are programmed by prenatal exposures to endocrine-disrupting chemicals.Molecular and cellular endocrinology · 2019Article
- Transgenerational effects of polychlorinated biphenyls: 1. Development and physiology across 3 generations of rats.Environmental health : a global access science source · 2018Article
- Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential.Stress (Amsterdam, Netherlands) · 2017Article
- Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex.Journal of neurogastroenterology and motility · 2017Article
- The effects of long-term estradiol treatment on social behavior and gene expression in adult female rats.Hormones and behavior · 2017Article
- Maternal Vitamin D Deficiency Programs Reproductive Dysfunction in Female Mice Offspring Through Adverse Effects on the Neuroendocrine Axis.Endocrinology · 2016Article
- Sexually dimorphic effects of gestational endocrine-disrupting chemicals on microRNA expression in the developing rat hypothalamus.Molecular and cellular endocrinology · 2015Article
- Testing the Critical Window Hypothesis of Timing and Duration of Estradiol Treatment on Hypothalamic Gene Networks in Reproductively Mature and Aging Female Rats.Endocrinology · 2015Article
- Hypothalamic molecular changes underlying natural reproductive senescence in the female rat.Endocrinology · 2014Article
- Sex-specific Esr2 mRNA expression in the rat hypothalamus and amygdala is altered by neonatal bisphenol A exposure.Reproduction (Cambridge, England) · 2014Article
- Dynamic postnatal developmental and sex-specific neuroendocrine effects of prenatal polychlorinated biphenyls in rats.Molecular endocrinology (Baltimore, Md.) · 2014Article
- A critical point of male gonad development: neuroendocrine correlates of accelerated testicular growth in rats during early life.PloS one · 2014Article
- Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging.Endocrinology · 2013Article
- MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects.Endocrinology · 2013Article
- Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdala.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice.Biology of reproduction · 2012Article
- Molecular profiling of postnatal development of the hypothalamus in female and male rats.Biology of reproduction · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Reproductive function is controlled by GnRH cells and their steroid-sensitive regulatory inputs. The proper maturation of this system is critical to sexual development and maintenance of adult function. However, the molecular mechanisms underlying these developmental changes, and the potential roles of gonadal hormones in sculpting these processes, have not been fully explored. We performed a developmental profile from postnatal day (P) 1 through P60 of a network of five genes in the preoptic area (POA) that are critical to reproduction in male Sprague Dawley rats. GnRH, estrogen receptors-alpha, and -beta, androgen receptor (AR), and progesterone receptor (PR) mRNAs in the POA were assayed, and serum hormones were measured, in developing male rats. We also used a Taqman low-density array to identify candidate genes that may be important in development. Of the five targeted genes, only AR and PR changed robustly (7- and 3- to 4-fold increases, respectively) during development. All of the gonadal serum hormones changed markedly and with very different patterns from their receptor mRNAs: testosterone decreased from P1 to P30 and then increased to P60; progesterone peaked on P30; and estradiol decreased from P1 to P30. Using the Taqman low-density array, we identified several genes that changed dramatically in the POA with development, particularly G protein-coupled receptor 30, IGF-I, vitamin D receptor, estrogen-related receptor-alpha, and thyroid receptor-alpha. Our data demonstrate developmental stage-specific changes in neuroendocrine genes, particularly AR and PR. Moreover, the relationships between hormones and their corresponding receptors undergo dynamic changes across development in male rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.