Evidence map›Paper›PMID 19147530›Full record

ReviewDNA research : an international journal for rapid publication of reports on genes and genomes2009

The human intestinal microbiome: a new frontier of human biology.

Masahira Hattori, Todd D Taylor

Registry-linked trialAbstract readReview
In one paragraph

Review in DNA research : an international journal for rapid publication of reports on genes and genomes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02428374 (Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study), which is not on this map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02428374 phase4unknown statusstarted 2015, after this paper: background citation

Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study (B And T Types of Lymphocytes Evaluation in Acute Myocardial Infarction)

Ran2015Enrolled300Registered outcomes30Posted comparisons0ConditionsMyocardial FibrosisArmsRosuvastatin plus clopidogrel, Rosuvastatin plus ticagrelor, Simvastatin plus clopidogrel, Simvastatin plus ticagrelor
Open the trial in the graph
3 · Its place in the literature

Who cites it

97 citing papers in PubMed.

  1. Trial
  2. Review
  3. The Japanese gut microbiome: ecology, uniqueness, and impact on health and disease.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026
    Review
  4. Article
  5. The Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Review
  8. Recent Applications of Artificial Intelligence in Discovery of New Antibacterial Agents.Advances and applications in bioinformatics and chemistry : AABC · 2024
    Review
  9. Review
  10. Article
  11. Journal of spine surgery (Hong Kong) · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Role of Gastric Microorganisms Other thanBioMed research international · 2022
    Review
  16. Review
  17. NAFLD in the Elderly.Clinical interventions in aging · 2021
    Review
  18. Review
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Masahira HattoriGraduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kasiwanoha, Kashiwa, Chiba 277-8561, Japan. hattori@k.u-tokyo.ac.jp
Todd D Taylor

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To analyze the vast number and variety of microorganisms inhabiting the human intestine, emerging metagenomic technologies are extremely powerful. The intestinal microbes are taxonomically complex and constitute an ecologically dynamic community (microbiota) that has long been believed to possess a strong impact on human physiology. Furthermore, they are heavily involved in the maturation and proliferation of human intestinal cells, helping to maintain their homeostasis and can be causative of various diseases, such as inflammatory bowel disease and obesity. A simplified animal model system has provided the mechanistic basis for the molecular interactions that occur at the interface between such microbes and host intestinal epithelia. Through metagenomic analysis, it is now possible to comprehensively explore the genetic nature of the intestinal microbiome, the mutually interacting system comprising the host cells and the residing microbial community. The human microbiome project was recently launched as an international collaborative research effort to further promote this newly developing field and to pave the way to a new frontier of human biology, which will provide new strategies for the maintenance of human health.

Indexed as

MetagenomeHumansInflammatory Bowel DiseasesIntestinal MucosaIntestinesModels, Biological

Identifiers

PMID19147530
PMCPMC2646358

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.