ArticleThe Journal of biological chemistry2009
Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Low-intensity ultrasound induces angiogenesis by activating endothelial integrin signaling in male mice.Physiological reports · 2026Article
- Multimodal rehabilitation for hard flaccid syndrome in a retrospective case series.Frontiers in rehabilitation sciences · 2026Article
- Low-intensity pulsed ultrasound in acute multiple rib fracture-a prospective analysis, randomized controlled trial and pilot study.Journal of thoracic disease · 2025Article
- Review
- Instructional review of key factors to achieve successful outcomes when using low-intensity pulsed ultrasound in fracture repair.EFORT open reviews · 2022Review
- Low-Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing: A Review.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022Review
- The Effects ofInternational journal of fertility & sterility · 2020Article
- Frequency-induced morphology alterations in microconfined biological cells.Medical & biological engineering & computing · 2019Article
- Clinically Available Low Intensity Ultrasound Devices do not Promote Axonal Regeneration After Peripheral Nerve Surgery-A Preclinical Investigation of an FDA-Approved Device.Frontiers in neurology · 2018Article
- Low-intensity pulsed ultrasound is effective for progressive-stage lumbar spondylolysis with MRI high-signal change.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity.Journal of cell science · 2017Article
- Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1.The Journal of investigative dermatology · 2015Article
- A syndecan-4 binding peptide derived from laminin 5 uses a novel PKCε pathway to induce cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells.Experimental cell research · 2014Article
- Induction of adhesion-dependent signals using low-intensity ultrasound.Journal of visualized experiments : JoVE · 2012Article
- Free radical formation from sonolysis of water in the presence of different gases.Journal of clinical biochemistry and nutrition · 2011Article
- The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures.Medical & biological engineering & computing · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The application of pulsed, low intensity ultrasound is emerging as a potent therapy for the treatment of complex bone fractures and tissue damage. Ultrasonic stimuli accelerate fracture healing by up to 40% and enhance tendon and ligament healing by promoting cell proliferation, migration, and matrix synthesis through an unresolved mechanism. Ultrasound treatment also induces closure of nonunion fractures, at a success rate (85% of cases) similar to that of surgical intervention (68-96%) while avoiding the complications associated with surgery. The regulation of cell adhesion necessary for wound healing depends on cooperative engagement of the extracellular matrix receptors, integrin and syndecan, as exemplified by the wound healing defects observed in syndecan- and integrin-knock-out mice. This report distinguishes the influence of ultrasound on signals downstream of the prototypic fibronectin receptors, alpha(5)beta(1) integrin and syndecan-4, which cooperate to regulate Rac1 and RhoA. Ultrasonic stimulation fails to activate integrins or induce cell spreading on poor, electrostatic ligands. By contrast, ultrasound treatment overcomes the necessity of engagement or expression of syndecan-4 during the process of focal adhesion formation, which normally requires simultaneous engagement of both receptors. Ultrasound exerts an influence downstream of syndecan-4 and PKCalpha to specifically activate Rac1, itself a critical regulator of tissue repair, and to a lesser extent RhoA. The ability of ultrasound to bypass syndecan-4 signaling, which is known to facilitate efficient tissue repair, explains the reduction in healing times observed in ultrasound-treated patients. By substituting for one of the key axes of adhesion-dependent signaling, ultrasound therapy has considerable potential as a clinical technique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.