Evidence map›Paper›PMID 19147078›Full record

ArticleBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2009

Multiple myeloma: biology, standard therapy, and transplant therapy.

Morie A Gertz, Irene Ghobrial, Jean Luc-Harousseau

Open access · bronzeAbstract read
In one paragraph

Article in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Morie A GertzDepartment of Medicine, Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Irene Ghobrial
Jean Luc-Harousseau
Centre Hospitalier Universitaire de Nantes · FRDana-Farber Cancer Institute · USMayo Clinic · US

Funding

CXCR4 regulation of tumor progression in Multiple MyelomaR01CA125690 · NCI · DANA-FARBER CANCER INST · PI GHOBRIAL, IRENE M. · 2008 to 2012
$1.6M
NCI NIH HHS R01 CA125690
6 · The paper itself

Abstract

The understanding of the pathogenesis of multiple myeloma has undergone a major transformation over the past eight years. New insights into the microenvironment of the plasma cell as well as elucidation of signaling pathways that prevent plasma cell apoptosis are leading to rapid new drug development. The introduction of novel agents has led to a significant increase in survival. Combinations of novel agents are expected to provide higher complete response rate with anticipated prolongation of relapse free and overall survival. Autologous and allogeneic stem cell transplantation remains an integral part of therapy further improving the outcomes following induction with novel agents.

Indexed as

Antineoplastic AgentsDrug Delivery SystemsHematopoietic Stem Cell TransplantationHumansMultiple MyelomaPlasma CellsAntineoplastic Agents

Identifiers

PMID19147078
PMCPMC3133635
OpenAlexW2156538208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.