ReviewCurrent topics in developmental biology2008
Cilia involvement in patterning and maintenance of the skeleton.
Review in Current topics in developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 86 citations in OpenAlex.
- The Role of the Hedgehog Pathway in Alcohol-Induced Birth Defects.Advances in experimental medicine and biology · 2026Review
- Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechano-adaptation.PloS one · 2026Article
- From polarity to pathology: Decoding the role of cell orientation in osteoarthritis.Journal of orthopaedic translation · 2024Review
- CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway.Medical oncology (Northwood, London, England) · 2024Article
- Identification of a novel variant of the ciliopathic gene FUZZY associated with craniosynostosis.European journal of human genetics : EJHG · 2022Article
- Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia.Bone research · 2022Article
- Primary Cilia: A Cellular Regulator of Articular Cartilage Degeneration.Stem cells international · 2022Review
- Primary cilia regulate gastric cancer-induced bone loss via cilia/Wnt/β-catenin signaling pathway.Aging · 2021Article
- Article
- The Primary Cilium on Cells of Developing Skeletal Rudiments; Distribution, Characteristics and Response to Mechanical Stimulation.Frontiers in cell and developmental biology · 2021Article
- Physiological and Pathophysiological Aspects of Primary Cilia-A Literature Review with View on Functional and Structural Relationships in Cartilage.International journal of molecular sciences · 2020Review
- Dental Anomalies in Rare, Genetic Ciliopathic Disorder-A Case Report and Review of Literature.International journal of environmental research and public health · 2020Review
- Primary cilia: Versatile regulator in cartilage development.Cell proliferation · 2020Review
- The Roles of Indian Hedgehog Signaling in TMJ Formation.International journal of molecular sciences · 2019Review
- Polygenic risk score for disability and insights into disability-related molecular mechanisms.GeroScience · 2019Article
- Association of IFT88 gene variants with nonsyndromic cleft lip with or without cleft palate.Birth defects research · 2019Article
- IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development.Cell death & disease · 2019Article
- Ciliary IFT80 regulates dental pulp stem cells differentiation by FGF/FGFR1 and Hh/BMP2 signaling.International journal of biological sciences · 2019Article
- The primary cilium as a signaling nexus for growth plate function and subsequent skeletal development.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Mechanobiology of limb musculoskeletal development.Annals of the New York Academy of Sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Although the expression of cilia on chondrocytes was described over 40 years ago, the importance of this organelle in skeletal development and maintenance has only recently been recognized. Primary cilia are found on most mammalian cells and have been shown to play a role in chemosensation and mechanosensation. A growing number of human pleiotropic syndromes have been shown to be associated with ciliary or basal body dysfunction. Skeletal phenotypes, including alterations in limb patterning, endochondral bone formation, craniofacial development, and dentition, have been described in several of these syndromes. Additional insights into the potential roles and mechanisms of cilia action in the mammalian skeleton have been provided by research in model organisms including mouse and zebrafish. In this article we describe what is currently known about the localization of cilia in the skeleton as well as the roles and underlying molecular mechanisms of cilia in skeletal development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.