ArticleReproductive biology and endocrinology : RB&E2009
Impact of GnRH ovarian stimulation protocols on intracytoplasmic sperm injection outcomes.
Article in Reproductive biology and endocrinology : RB&E, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gonadotrophin-releasing hormone antagonists for assisted reproductive technology.The Cochrane database of systematic reviews · 2016Pooled it
- Oocyte maturation triggers in high-responders: a report on 1,217 consecutive cycles.Reproduction & fertility · 2025Article
- Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis.EBioMedicine · 2023Article
- In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes.JBRA assisted reproduction · 2023Review
- Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients.JBRA assisted reproduction · 2022Article
- Novel nomogram-based integrated gonadotropin therapy individualization in in vitro fertilization/intracytoplasmic sperm injection: A modeling approach.Clinical and experimental reproductive medicine · 2021Article
- Discordance between human sperm quality and telomere length following differential gradient separation/swim-up.Journal of assisted reproduction and genetics · 2020Article
- Clinical outcomes of microdissection testicular sperm extraction and intracytoplasmic sperm injection in Japanese men with Y chromosome microdeletions.Reproductive medicine and biology · 2020Article
- Corino de Andrade disease: mechanisms and impact on reproduction.JBRA assisted reproduction · 2017Review
- Ultrastructural and cytogenetic analyses of mature human oocyte dysmorphisms with respect to clinical outcomes.Journal of assisted reproduction and genetics · 2016Article
- Ovarian hyperstimulation syndrome: a clinical report on 4894 consecutive ART treatment cycles.Reproductive biology and endocrinology : RB&E · 2015Article
- Molecular cytogenetics of human single pronucleated zygotes.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Effect of polyvinylpyrrolidone on sperm function and early embryonic development following intracytoplasmic sperm injection in human assisted reproduction.Reproductive medicine and biology · 2012Article
- Observational Study to Assess the Therapeutic Value of Four Ovarian Hyperstimulation Protocols in IVF After Pituitary Suppression with GnRH Antagonists in Normally Responding Women.Clinical medicine insights. Reproductive health · 2011Article
- Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia.Asian journal of andrologyArticle
- Comparison of intracytoplasmic sperm injection (ICSI) outcomes in infertile men with spermatogenic impairment of differing severity.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
backgroundAlthough a large number of studies have been conducted in relation to ovarian response and pregnancy after GnRH agonist and GnRH antagonist controlled ovarian hyperstimulation protocols, most of them used single or combinations of a few predictive factors, and none included the stimulation protocol in the multivariable analysis. The present study was thus primarily designed to investigate the predictive value of the stimulation protocol and to analyze the possible relationships between stimulation protocols and treatment outcomes after adjusting for a large set of variables that potentially affect reproductive outcomes. Factors related to pregnancy achievement and predictive of the number of oocytes retrieved and high quality of the embryos obtained were also analyzed.
methodsTo analyze the impact of GnRH ovarian stimulation protocols on the independent predictors of ovarian response, high quality embryos and clinical pregnancy, two groups out of 278 ICSI treatment cycles were compared prospectively, 123 with a GnRH agonist and 155 with a GnRH antagonist, with multivariable analysis assessing outcomes after adjusting for a large set of variables.
resultsAntagonists were significantly associated with lower length and total dose of GnRH, lower length of rFSH, and higher numbers of oocytes and high quality embryos, whereas the agonist presented a higher fertilization rate and probability of pregnancy. Significant predictors of retrieved oocytes and high quality embryos were the antagonist protocol, lower female age, lower serum levels of basal FSH and higher total number of antral follicles. Significant predictors of clinical pregnancy were the agonist protocol, reduced number of attempts, increased endometrial thickness and lower female age. The probability of pregnancy increased until 30 years-old, with a decline after that age and with a sharp decline after 40 years-old.
conclusionThe models found suggest that not only the protocol but also factors as female age, basal FSH, antral follicles, number of attempts and endometrial thickness should be analyzed for counselling patients undergoing an ICSI treatment.
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