ArticleBMC genetics2009
Mapping of five candidate sex-determining loci in rainbow trout (Oncorhynchus mykiss).
Article in BMC genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Identification and Genomic Localization of Autosomal sdY Locus in a Population of Atlantic Salmon (Salmo salar).Marine biotechnology (New York, N.Y.) · 2023Article
- Lessons from an unusual vertebrate sex-determining gene.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Integrated gene mapping and synteny studies give insights into the evolution of a sex proto-chromosome in Solea senegalensis.Chromosoma · 2017Article
- Mapping of DNA sex-specific markers and genes related to sex differentiation in turbot (Scophthalmus maximus).Marine biotechnology (New York, N.Y.) · 2012Article
- Differential gene expression in male and female rainbow trout embryos prior to the onset of gross morphological differentiation of the gonads.BMC genomics · 2011Article
- Clock genes and their genomic distributions in three species of salmonid fishes: Associations with genes regulating sexual maturation and cell cycling.BMC research notes · 2010Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRainbow trout have an XX/XY genetic mechanism of sex determination where males are the heterogametic sex. The homology of the sex-determining gene (SDG) in medaka to Dmrt1 suggested that SDGs evolve from downstream genes by gene duplication. Orthologous sequences of the major genes of the mammalian sex determination pathway have been reported in the rainbow trout but the map position for the majority of these genes has not been assigned.
resultsFive loci of four candidate genes (Amh, Dax1, Dmrt1 and Sox6) were tested for linkage to the Y chromosome of rainbow trout. We exclude the role of all these loci as candidates for the primary SDG in this species. Sox6i and Sox6ii, duplicated copies of Sox6, mapped to homeologous linkage groups 10 and 18 respectively. Genotyping fishes of the OSU x Arlee mapping family for Sox6i and Sox6ii alleles indicated that Sox6i locus might be deleted in the Arlee lineage.
conclusionAdditional candidate genes should be tested for their linkage to the Y chromosome. Mapping data of duplicated Sox6 loci supports previously suggested homeology between linkage groups 10 and 18. Enrichment of the rainbow trout genomic map with known gene markers allows map comparisons with other salmonids. Mapping of candidate sex-determining loci is important for analyses of potential autosomal modifiers of sex-determination in rainbow trout.
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