ArticleLearning & memory (Cold Spring Harbor, N.Y.)2009
Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed.
- Stimulus Contingency and Task Context Encoding within the Anterior Cingulate-Amygdala-Cerebellum Associative Learning Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- Fast implicit and slow explicit learning of temporal context.Scientific reports · 2025Article
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Cerebellar contribution to the regulation of defensive states.Frontiers in systems neuroscience · 2023Review
- Ventromedial Thalamus-Projecting DCN Neurons Modulate Associative Sensorimotor Responses in Mice.Neuroscience bulletin · 2022Article
- Role of cerebellar cortex in associative learning and memory in guinea pigs.Open life sciences · 2022Article
- Hippocampal Interneurons are Required for Trace Eyeblink Conditioning in Mice.Neuroscience bulletin · 2021Article
- Recent Advances in the Understanding of Specific Efferent Pathways Emerging From the Cerebellum.Frontiers in neuroanatomy · 2021Review
- Cortico-cerebellar interactions during goal-directed behavior.Current opinion in neurobiology · 2020Review
- Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning.Behavioural brain research · 2020Article
- Response to "Fallacies of Mice Experiments".Neuroinformatics · 2019Article
- Different brain networks mediate the effects of social and conditioned expectations on pain.Nature communications · 2019Article
- Reevaluating the ability of cerebellum in associative motor learning.Scientific reports · 2019Article
- A cortico-cerebellar loop for motor planning.Nature · 2018Article
- Medial Auditory Thalamus Is Necessary for Expression of Auditory Trace Eyelid Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Cerebellar Processing Common to Delay and Trace Eyelid Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Medial Prefrontal Cortex-Pontine Nuclei Projections Modulate Suboptimal Cue-Induced Associative Motor Learning.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Eyelid conditioning has proven useful for analysis of learning and computation in the cerebellum. Two variants, delay and trace conditioning, differ only by the relative timing of the training stimuli. Despite the subtlety of this difference, trace eyelid conditioning is prevented by lesions of the cerebellum, hippocampus, or medial prefrontal cortex (mPFC), whereas delay eyelid conditioning is prevented by cerebellar lesions and is largely unaffected by forebrain lesions. Here we test whether these lesion results can be explained by two assertions: (1) Cerebellar learning requires temporal overlap between the mossy fiber inputs activated by the tone conditioned stimulus (CS) and the climbing fiber inputs activated by the reinforcing unconditioned stimulus (US), and therefore (2) trace conditioning requires activity that outlasts the presentation of the CS in a subset of mossy fibers separate from those activated directly by the CS. By use of electrical stimulation of mossy fibers as a CS, we show that cerebellar learning during trace eyelid conditioning requires an input that persists during the stimulus-free trace interval. By use of reversible inactivation experiments, we provide evidence that this input arises from the mPFC and arrives at the cerebellum via a previously unidentified site in the pontine nuclei. In light of previous PFC recordings in various species, we suggest that trace eyelid conditioning involves an interaction between the persistent activity of delay cells in mPFC-a putative mechanism of working memory-and motor learning in the cerebellum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.