ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Research progress on oxidative stress regulating different types of neuronal death caused by epileptic seizures.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Properties of GABAergic Neurons Containing Calcium-Permeable Kainate and AMPA-Receptors.Life (Basel, Switzerland) · 2021Article
- NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.Molecular neurobiology · 2019Article
- Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Stereotypical patterns of epileptiform calcium signal in hippocampal CA1, CA3, dentate gyrus and entorhinal cortex in freely moving mice.Scientific reports · 2019Article
- Whole-cell Currents Induced by Puff Application of GABA in Brain Slices.Journal of visualized experiments : JoVE · 2017Article
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.Cell reports · 2017Article
- Diverse roles for ionotropic glutamate receptors on inhibitory interneurons in developing and adult brain.The Journal of physiology · 2016Review
- Different AMPA receptor subtypes mediate the distinct kinetic components of a biphasic EPSC in hippocampal interneurons.Frontiers in synaptic neuroscience · 2015Article
- Galantamine prevents long-lasting suppression of excitatory synaptic transmission in CA1 pyramidal neurons of soman-challenged guinea pigs.Neurotoxicology · 2014Article
- Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Dendritic inhibition mediated by O-LM and bistratified interneurons in the hippocampus.Frontiers in synaptic neuroscience · 2014Review
- Article
- Synaptic kainate receptors in CA1 interneurons gate the threshold of theta-frequency-induced long-term potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Presynaptic facilitation of glutamate release in the basolateral amygdala: a mechanism for the anxiogenic and seizurogenic function of GluK1 receptors.Neuroscience · 2012Article
- Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia.PloS one · 2012Article
- Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.Nature neuroscience · 2011Article
- Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG.Frontiers in neural circuits · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Kainate receptors (KARs) contribute to postsynaptic excitation in only a select subset of neurons. To define the parameters that specify the postsynaptic expression of KARs, we examined the contribution of KARs to EPSCs on hippocampal interneurons in area CA1. Interneurons in stratum radiatum/lacunosum-moleculare express KARs both with and without the GluR5 subunit, but KAR-mediated EPSCs are generated mainly, if not entirely, by GluR5-containing KARs. Extrasynaptic glutamate spillover profoundly recruits AMPA receptors (AMPARs) with little effect on KARs, indicating that KARs are targeted at the synapse more precisely than AMPARs. However, spontaneous EPSCs with a conventional AMPAR component did not have a resolvable contribution of KARs, suggesting that the KARs that contribute to the evoked EPSCs are at a distinct set of synapses. GluR5-containing KARs on interneurons in stratum oriens do not contribute substantially to the EPSC. We conclude that KARs are localized to synapses by cell type-, synapse-, and subunit-selective mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.