ArticleJournal of clinical microbiology2009
Role of SCCmec type in outcome of Staphylococcus aureus bacteremia in a single medical center.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates.Antimicrobial agents and chemotherapy · 2011Trial
- Clinical outcomes by methicillin-resistant Staphylococcus aureus staphylococcal cassette chromosome mec type: isolates recovered from a phase IV clinical trial of linezolid and vancomycin for complicated skin and skin structure infections.Antimicrobial agents and chemotherapy · 2010Trial
- InJournal of bacteriology · 2026Article
- InbioRxiv : the preprint server for biology · 2026Article
- Comparison of disease and economic burden between MRSA infection and MRSA colonization in a university hospital: a retrospective data integration study.Antimicrobial resistance and infection control · 2024Article
- Persistent Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Review
- Staphylococcal Cassette ChromosomeInfection and drug resistance · 2022Article
- A new simplified predictive model for mortality in methicillin-resistant Staphylococcus aureus bacteremia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Colonization of HIV-Infected Children with Methicillin-ResistantPathogens (Basel, Switzerland) · 2019Article
- Article
- Is methicillin-resistantRisk management and healthcare policy · 2018Article
- Prevalence and molecular characteristics of Staphylococcus aureus, including methicillin resistant strains, isolated from bulk can milk and raw milk products in pastoral communities of South-West Uganda.BMC infectious diseases · 2017Article
- Association between Accessory Gene Regulator Polymorphism and Mortality among Critically Ill Patients Receiving Vancomycin for Nosocomial MRSA Bacteremia: A Cohort Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2016Article
- Poorly Cross-Linked Peptidoglycan in MRSA Due to mecA Induction Activates the Inflammasome and Exacerbates Immunopathology.Cell host & microbe · 2015Article
- agr dysfunction affects staphylococcal cassette chromosome mec type-dependent clinical outcomes in methicillin-resistant Staphylococcus aureus bacteremia.Antimicrobial agents and chemotherapy · 2015Article
- The multifaceted resources and microevolution of the successful human and animal pathogen methicillin-resistant Staphylococcus aureus.Memorias do Instituto Oswaldo Cruz · 2014Review
- Where does a Staphylococcus aureus vaccine stand?Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2014Review
- Association between susceptibility to photodynamic oxidation and the genetic background of Staphylococcus aureus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- A comparison of clinical outcomes between healthcare-associated infections due to community-associated methicillin-resistant Staphylococcus aureus strains and healthcare-associated methicillin-resistant S. aureus strains.Epidemiology and infection · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus virulence factors may determine infection presentation. Whether SCCmec type-associated factors play a role in S. aureus bacteremia is unclear. We conducted a prospective observation of adult inpatients with S. aureus bacteremia (1 November 2005 to 31 December 2006), performed SCCmec typing of methicillin-resistant S. aureus (MRSA) isolates, and stratified the results according to SCCmec type. We studied 253 patients. MRSA accounted for 163 (64.4%) cases. The illness severity index was similar in MRSA and methicillin-sensitive S. aureus (MSSA) cases. MRSA caused higher in-hospital mortality (23.9% versus 8.9%; P=0.003), longer bacteremia (4.7+/-6.5 days versus 2.7+/-2.9 days; P=0.01), but similar metastatic infection (14.7% versus 15.6%). Stratifying the results according to SCCmec type revealed significant differences. SCCmec type II caused highest mortality (33.3%) versus type IVa (13.5%), other MRSA (12.5%), and MSSA (8.9%). SCCmec IVa produced the highest metastatic infection (26.9% versus 9.1% [SCCmec II], 8.3% [other MRSA], and 15.6% [MSSA]). Persistent bacteremia (>or= 7 days) was similar in all SCCmec types (16.7 to 20.7%); each exceeded MSSA (6.7%; P=0.05). In multivariate analysis, SCCmec II was a predictor of mortality (odds ratio [OR]=3.73; 95% confidence interval [CI] = 1.81 to 7.66; P=0.009), SCCmec IVa was a predictor of metastatic infection (OR=3.52; CI=1.50 to 8.23; P=0.004), and MRSA (independent of SCCmec type) was a predictor of persistent bacteremia (OR=4.16; CI=1.47 to 11.73; P=0.007). These findings suggest that SCCmec-associated virulence factors play a role in the outcome of S. aureus bacteremia. Additional studies are needed to identify which virulence factors are the determinants of increased mortality with SCCmec type II and metastatic infection with SCCmec type IVa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.