Evidence map›Paper›PMID 19144791›Full record

ArticleClinical and vaccine immunology : CVI2009

Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis.

Stephen P Saville, Anna L Lazzell, Ashok K Chaturvedi, Carlos Monteagudo, Jose L Lopez-Ribot

Open access · diamondAbstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 52 citations in OpenAlex.

  1. A Comprehensive Overview ofJournal of fungi (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Vaccines against candidiasis: Status, challenges and emerging opportunity.Frontiers in cellular and infection microbiology · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Primary Cutaneous Coccidioidomycosis: An Update.American journal of clinical dermatology · 2020
    Review
  17. The Rise ofFrontiers in immunology · 2019
    Review
  18. Experimental in Vivo Models of Candidiasis.Journal of fungi (Basel, Switzerland) · 2018
    Review
  19. The Elusive Anti-Frontiers in immunology · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Stephen P SavilleDepartment of Biology and South Texas Center for Emerging Infectious Diseases, the University of Texas at San Antonio, San Antonio, Texas 78249, USA.
Anna L Lazzell
Ashok K Chaturvedi
Carlos Monteagudo
Jose L Lopez-Ribot
Texas Center for Infectious Disease · USUniversitat de València · ES

Funding

Host Immunity and Virulence in Candida albicans PathogenesisR01AI064562 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI LOPEZ-RIBOT, JOSE L. · 2006 to 2009
$1.4M
NRG1 Regulated Genes in Candida albicans PathogenicityR01AI063256 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI SAVILLE, STEPHEN P · 2006 to 2009
$1.1M
NIAID NIH HHS R01 AI063256NIAID NIH HHS R01AI063256NIAID NIH HHS R01 AI064562NIAID NIH HHS R01AI064562
6 · The paper itself

Abstract

We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.

Indexed as

AnimalsCandida albicansCandidiasisFungal VaccinesMiceNeuregulin-1Survival AnalysisT-LymphocytesVaccines, AttenuatedVaccines, SyntheticFungal VaccinesNeuregulin-1Vaccines, AttenuatedVaccines, Synthetic

Identifiers

PMID19144791
PMCPMC2650868
OpenAlexW2119042935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.