ArticleClinical and vaccine immunology : CVI2009
Role of Toll-like receptors in activation of porcine alveolar macrophages by porcine reproductive and respiratory syndrome virus.
Article in Clinical and vaccine immunology : CVI, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Ligation of the CD163 molecule inhibits the synthesis of type I and type III interferons in porcine alveolar macrophages.BMC veterinary research · 2026Article
- Advances in the immunosuppression of porcine reproductive and respiratory syndrome virus.Frontiers in veterinary science · 2026Review
- PRRSV non-structural protein 5 inhibits antiviral innate immunity by degrading multiple proteins of RLR signaling pathway through FAM134B-mediated ER-phagy.Journal of virology · 2024Article
- Evasion strategies of porcine reproductive and respiratory syndrome virus.Frontiers in microbiology · 2023Review
- Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus.Frontiers in microbiology · 2021Review
- Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection.BMC genomics · 2020Article
- Silence of TGF-β1 gene expression reduces prrsv replication and potentiates immunity of immune cells of tibetan pig.Veterinary and animal science · 2019Article
- Genotype 2 Strains of Porcine Reproductive and Respiratory Syndrome Virus Dysregulate Alveolar Macrophage Cytokine Production via the Unfolded Protein Response.Journal of virology · 2018Article
- Nuclear imprisonment of host cellular mRNA by nsp1β protein of porcine reproductive and respiratory syndrome virus.Virology · 2017Article
- Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway.Scientific reports · 2016Article
- Innate and adaptive immunity against Porcine Reproductive and Respiratory Syndrome Virus.Veterinary immunology and immunopathology · 2015Review
- Modulation of innate immune signaling by nonstructural protein 1 (nsp1) in the family Arteriviridae.Virus research · 2014Review
- The porcine innate immune system: an update.Developmental and comparative immunology · 2014Review
- Comparative expression of Toll-like receptors and inflammatory cytokines in pigs infected with different virulent porcine reproductive and respiratory syndrome virus isolates.Virology journal · 2013Article
- Article
- Suppression of immune responses in pigs by nonstructural protein 1 of porcine reproductive and respiratory syndrome virus.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2012Article
- Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus.Viruses · 2012Review
- Evaluation of suitable reference genes for gene expression studies in porcine alveolar macrophages in response to LPS and LTA.BMC research notes · 2012Article
- The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals.PloS one · 2012Article
- Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control of virus replication initially depends on rapid activation of the innate immune response. Toll-like receptor (TLR) ligands are potent inducers of innate immunity against viral infections. Porcine reproductive and respiratory syndrome virus (PRRSV), a positive-sense RNA virus, initiates infection in porcine alveolar macrophages (PAMs), elicits weak immune responses, and establishes a persistent infection. To understand the role of single-stranded RNA and double-stranded RNA (dsRNA) intermediates in eliciting host immunity, we sought to determine if TLRs, particularly those that respond to viral molecular patterns, are involved in PRRSV infection. Activation of TLR3 in PAMs with dsRNA increased gene expression for alpha interferon and suppressed PRRSV infectivity. In contrast, TLR4 activation by the treatment of PAMs with lipopolysaccharide did not influence PRRSV infectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.