ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Aging augments mitochondrial susceptibility to heat stress.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Oxidative Stress-Associated Alterations in Sperm ACTL7A Expression and Function in Men With Varicocele.Oxidative medicine and cellular longevity · 2026Article
- Chronic Kidney Disease of Unknown Etiology: A Global Health Threat in Rural Agricultural Communities-Prevalence, Suspected Causes, Mechanisms, and Prevention Strategies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- A germline-to-soma signal triggers an age-related decline of mitochondrial stress response.Nature communications · 2024Article
- Altered accumulation of hepatic mitochondrial antioxidant proteins with age and environmental heat stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Radical Response: Effects of Heat Stress-Induced Oxidative Stress on Lipid Metabolism in the Avian Liver.Antioxidants (Basel, Switzerland) · 2020Review
- Aging results in accumulation of M1 and M2 hepatic macrophages and a differential response to gadolinium chloride.Histochemistry and cell biology · 2020Article
- Endothelial TNF-α induction by Hsp60 secreted from THP-1 monocytes exposed to hyperglycaemic conditions.Cell stress & chaperones · 2018Article
- Sexual dimorphism in the hepatic protein response to a moderate trans fat diet in senescence-accelerated mice.Lipids in health and disease · 2017Article
- To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss.Oncotarget · 2015Article
- Functional diversification and specialization of cytosolic 70-kDa heat shock proteins.Scientific reports · 2015Article
- Aging impairs induction of redox factor-1 after heat stress: a potential mechanism for heat-induced liver injury.International journal of physiology, pathophysiology and pharmacology · 2015Article
- Understanding the role of heat shock protein isoforms in male fertility, aging and apoptosis.The world journal of men's health · 2014Review
- Altered expression of iron regulatory proteins with aging is associated with transient hepatic iron accumulation after environmental heat stress.Blood cells, molecules & diseases · 2014Article
- Article
- Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people.Cell stress & chaperones · 2012Article
- Cellular stress response pathways and ageing: intricate molecular relationships.The EMBO journal · 2011Review
- Heat shock proteins modulate keloid formation.Eplasty · 2011Article
- Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver.Archives of gerontology and geriatricsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The pathophysiology of aging is accompanied by a decline in tolerance to environmental stress. While mitochondria are primary suspects in the etiology of aging, little is known about their ability to tolerate perturbations to homeostasis in older organisms. To investigate the role of mitochondria in the increased susceptibility to heat stress that accompanies aging, young and old Fischer 344 rats underwent a heat stress protocol known to elicit exaggerated cellular damage with aging. At either 2 or 24 h after heat stress, livers were removed from animals, and hepatic mitochondria were isolated. Electron microscopy revealed extensive morphological damage to mitochondria from young and, to a greater extent, old rats after heat stress. There was also a significant loss of cytochrome c from old, but not young, mitochondria and a persistent increase in 4-hydroxynonenal-modified proteins in old vs. young mitochondria exposed to heat stress. Electron paramagnetic resonance measurements of superoxide indicate greater superoxide production from mitochondria of old compared with young animals and suggest that mitochondrial integrity was altered during heat stress. The mitochondrial stress response, which functions to correct stress-induced damage to mitochondrial proteins, was also blunted in old rats. Delayed and reduced levels of heat shock protein 60 (Hsp60), the main inducible mitochondrial stress protein, were observed in old compared with young mitochondria after heat stress. Additionally, the amount of Hsp10 protein increased in young, but not old, rat liver mitochondria after hyperthermic challenge. Taken together, these data suggest that mitochondria in old animals are more vulnerable to incurring and less able to repair oxidative damage that occurs in response to a physiologically relevant heat stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.