ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Characterization of the chemosensitive response of individual solitary complex neurons from adult rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Nucleus Tractus Solitarius Neurons Activated by Hypercapnia and Hypoxia Lack Mu Opioid Receptor Expression.Frontiers in molecular neuroscience · 2022Article
- The OFrontiers in physiology · 2022Review
- Article
- Modulation of hypercapnic respiratory response by cholinergic transmission in the commissural nucleus of the solitary tract.Pflugers Archiv : European journal of physiology · 2020Article
- Theoretical perspectives on central chemosensitivity: CO2/H+-sensitive neurons in the locus coeruleus.PLoS computational biology · 2017Article
- Anatomical and functional connections between the locus coeruleus and the nucleus tractus solitarius in neonatal rats.Neuroscience · 2016Article
- Purinergic signalling contributes to chemoreception in the retrotrapezoid nucleus but not the nucleus of the solitary tract or medullary raphe.The Journal of physiology · 2014Article
- Serotonin neurons and central respiratory chemoreception: where are we now?Progress in brain research · 2014Review
- Substance P differentially modulates firing rate of solitary complex (SC) neurons from control and chronic hypoxia-adapted adult rats.PloS one · 2014Article
- Transient outwardly rectifying A currents are involved in the firing rate response to altered CO2 in chemosensitive locus coeruleus neurons from neonatal rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- pH modulation of glial glutamate transporters regulates synaptic transmission in the nucleus of the solitary tract.Journal of neurophysiology · 2013Article
- Postnatal development and activation of L-type Ca2+ currents in locus ceruleus neurons: implications for a role for Ca2+ in central chemosensitivity.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Serotonergic neurons in the nucleus raphe obscurus contribute to interaction between central and peripheral ventilatory responses to hypercapnia.Pflugers Archiv : European journal of physiology · 2011Article
- Ventilatory effects of substance P-saporin lesions in the nucleus tractus solitarii of chronically hypoxic rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- The locus coeruleus and central chemosensitivity.Respiratory physiology & neurobiology · 2010Review
- CO2 chemoreception in cardiorespiratory control.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Contributions of central and peripheral chemoreceptors to the ventilatory response to CO2/H+.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Chronic hypoxia suppresses the CO2 response of solitary complex (SC) neurons from rats.Respiratory physiology & neurobiology · 2009Article
- Chemosensory responses to CO2 in multiple brain stem nuclei determined using a voltage-sensitive dye in brain slices from rats.Journal of neurophysiology · 2009Article
- Medullary serotonin neurons and central CO2 chemoreception.Respiratory physiology & neurobiology · 2009Review
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Authors and funding
6 authors.
Funding
Abstract
We studied the CO(2)/H(+)-chemosensitive responses of individual solitary complex (SC) neurons from adult rats by simultaneously measuring the intracellular pH (pH(i)) and electrical responses to hypercapnic acidosis (HA). SC neurons were recorded using the blind whole cell patch-clamp technique and loading the soma with the pH-sensitive dye pyranine through the patch pipette. We found that SC neurons from adult rats have a lower steady-state pH(i) than SC neurons from neonatal rats. In the presence of chemical and electrical synaptic blockade, adult SC neurons have firing rate responses to HA (percentage of neurons activated or inhibited and the magnitude of response as determined by the chemosensitivity index) that are similar to SC neurons from neonatal rats. They also have a typical response to isohydric hypercapnia, including decreased DeltapH(i), followed by pH(i) recovery, and increased firing rate. Thus, the chemosensitive response of SC neurons from adults is similar to the chemosensitive response of SC neurons from neonatal rats. Because our findings for adults are similar to previously reported values for neurons from neonatal rats, we conclude that intrinsic chemosensitivity is established early in development for SC neurons and is maintained throughout adulthood.
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