ArticleJournal of neurophysiology2009
Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03096444 (Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine), which is not on this map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine
Who cites it
49 citing papers in PubMed, 95 citations in OpenAlex.
- Nocebo Effects on Cowhage-evoked Itch: A Randomized Controlled Trial of Classical Conditioning and Observational Learning.Acta dermato-venereologica · 2021Trial
- Sensory responses to injection and punctate application of capsaicin and histamine to the skin.Pain · 2011Trial
- Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.PloS one · 2011Trial
- Trial
- Affective touch reduces histamine evoked itch experience.PloS one · 2025Article
- Peripheral signaling pathways contributing to non-histaminergic itch in humans.Journal of translational medicine · 2023Article
- How Does Botulinum Toxin Inhibit Itch?Toxins · 2022Review
- Evaluation of itch and pain induced by bovine adrenal medulla (BAM)8-22, a new human model of non-histaminergic itch.Experimental dermatology · 2022Article
- Punctate Administration of Ficin as a human and animal model of non-histaminergic itch.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Article
- Induction and generalization of nocebo effects on itch.Experimental dermatology · 2022Article
- Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain.International journal of molecular sciences · 2022Article
- Acute Itch Induces Attentional Avoidance of Itch-related Information.Acta dermato-venereologica · 2022Article
- Effects of Salicornia-Based Skin Cream Application on Healthy Humans' Experimental Model of Pain and Itching.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study.Acta dermato-venereologica · 2021Observational
- Article
- Thermal Hyperalgesia and Mechanical Allodynia Elicited by Histamine and Non-histaminergic Itch Mediators: Respective Involvement of TRPV1 and TRPA1.Neuroscience · 2020Article
- A spinal neural circuitry for converting touch to itch sensation.Nature communications · 2020Article
- Physiology and Pathophysiology of Itch.Physiological reviews · 2020Review
- The Challenge of Basic Itch Research.Acta dermato-venereologica · 2020Review
- Flare Size but Not Intensity Reflects Histamine-Induced Itch.Skin pharmacology and physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Although the trichomes (spicules) of a pod of cowhage (Mucuna pruriens) are known to evoke a histamine-independent itch that is mediated by a cysteine protease, little is known of the itch and accompanying nociceptive sensations evoked by a single spicule and the enhanced itch and pain that can occur in the surrounding skin. The tip of a single spicule applied to the forearm of 45 subjects typically evoked 1) itch accompanied by nociceptive sensations (NS) of pricking/stinging and, to a lesser extent, burning, and 2) one or more areas of cutaneous dysesthesia characterized by hyperknesis (enhanced itch to pricking) with or without alloknesis (itch to stroking) and/or hyperalgesia (enhanced pricking pain). Itch could occur in the absence of NS or one or more dysesthesias but very rarely the reverse. The peak magnitude of sensation was positively correlated for itch and NS and increased (exhibited spatial summation) as the number of spicules was increased within a spatial extent of 6 cm but not 1 cm. The areas of dysesthesia did not exhibit spatial summation. We conclude that itch evoked by a punctate chemical stimulus can co-exist with NS and cutaneous dysesthesias as may occur in clinical pruritus. However, cowhage itch was not always accompanied by NS or dysesthesia nor was a momentary change in itch necessarily accompanied by a similar change in NS or vice versa. Thus there may be separate neural coding mechanisms for itch, nociceptive sensations, and each type of dysesthesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.