ArticleMagnetic resonance imaging2009
Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging.
Article in Magnetic resonance imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Quality Assurance Strategies for Brain State Characterization by MEMRI.bioRxiv : the preprint server for biology · 2026Article
- Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases.Frontiers in neurology · 2020Review
- Anatomy, Functionality, and Neuronal Connectivity with Manganese Radiotracers for Positron Emission Tomography.Molecular imaging and biology · 2018Article
- Development of manganese-enhanced magnetic resonance imaging of the rostral ventrolateral medulla of conscious rats: Importance of normalization and comparison with other regions of interest.NMR in biomedicine · 2018Article
- Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration.Frontiers in aging neuroscience · 2018Review
- Manganese Enhanced MRI for Use in Studying Neurodegenerative Diseases.Frontiers in neural circuits · 2018Review
- Article
- Blast-Induced Tinnitus and Elevated Central Auditory and Limbic Activity in Rats: A Manganese-Enhanced MRI and Behavioral Study.Scientific reports · 2017Article
- Manganese-enhanced magnetic resonance imaging combined with electrophysiology in the evaluation of visual pathway in experimental rat models with monocular blindness.Brain and behavior · 2017Article
- Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI.Scientific reports · 2017Article
- Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation.NeuroImage · 2016Article
- Manganese-Enhanced MRI: Biological Applications in Neuroscience.Frontiers in neurology · 2015Review
- Testing the calcium hypothesis of aging in the rat hippocampus in vivo using manganese-enhanced MRI.Neurobiology of aging · 2014Article
- Mapping of the mouse olfactory system with manganese-enhanced magnetic resonance imaging and diffusion tensor imaging.Brain structure & function · 2013Article
- Brain processing of biologically relevant odors in the awake rat, as revealed by manganese-enhanced MRI.PloS one · 2012Article
- Article
- From axonal transport to mitochondrial trafficking: What can we learn from Manganese-Enhanced MRI studies in mouse models of Alzheimers disease?Current medical imaging reviews · 2011Article
- Article
- In vivo detection of individual glomeruli in the rodent olfactory bulb using manganese enhanced MRI.NeuroImage · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Manganese enhanced MRI (MEMRI) is an emerging technique for tracing neuronal pathways in vivo. However, manganese may leak into blood vessels or cerebrospinal fluid (CSF) after local injection and can be circulated to and taken up by brain regions that may not have connections to the targeted pathways. Comparing enhancement time courses after intranasal injection with intravenous infusion of MnCl(2) in rats, the early enhancements in the pituitary gland (Pit) and hippocampus indicate the contrasts in those regions in the olfactory tract-tracing experiment were caused by such systemic effects. Since the Pit has easy access to manganese from the blood and its signal is proportional to other brain regions after intravenous infusion, it was used as an internal reference for the systemic effects. Applying intensity normalization by the Pit signal to tract-tracing data from the olfactory bulb led to reduced contrast in the hippocampus. These results demonstrate that nonspecific enhancements in MEMRI tract-tracing studies may have to be taken into account and that normalization by the Pit signal can compensate these effects.
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