ArticleBiomaterials2009
Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury.
Article in Biomaterials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 97 citations in OpenAlex.
- Building-Block Size Mediates Microporous Annealed Particle Hydrogel Tube Microenvironment Following Spinal Cord Injury.Advanced healthcare materials · 2024Article
- Current Concepts of Biomaterial Scaffolds and Regenerative Therapy for Spinal Cord Injury.International journal of molecular sciences · 2023Review
- Extra Cellular Matrix Remodeling: An Adjunctive Target for Spinal Cord Injury and Intervertebral Disc Degeneration.Neurospine · 2022Article
- Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation.NPJ Regenerative medicine · 2021Article
- Thermosensitive collagen/fibrinogen gels loaded with decorin suppress lesion site cavitation and promote functional recovery after spinal cord injury.Scientific reports · 2021Article
- Controlling Structure with Injectable Biomaterials to Better Mimic Tissue Heterogeneity and Anisotropy.Advanced healthcare materials · 2021Review
- Screening a chemically defined extracellular matrix mimetic substrate library to identify substrates that enhance substrate-mediated transfection.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Tubular scaffold with microchannels and an H-shaped lumen loaded with bone marrow stromal cells promotes neuroregeneration and inhibits apoptosis after spinal cord injury.Journal of tissue engineering and regenerative medicine · 2020Article
- Cell Therapeutic Strategies for Spinal Cord Injury.Advances in wound care · 2019Review
- It's All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Review
- Non-viral gene delivery systems for tissue repair and regeneration.Journal of translational medicine · 2018Review
- Numerical characterization of regenerative axons growing along a spherical multifunctional scaffold after spinal cord injury.PloS one · 2018Article
- "Tissue Papers" from Organ-Specific Decellularized Extracellular Matrices.Advanced functional materials · 2017Article
- Tissue Engineering Approaches to Modulate the Inflammatory Milieu following Spinal Cord Injury.Cells, tissues, organs · 2016Review
- Bridging the lesion-engineering a permissive substrate for nerve regeneration.Regenerative biomaterials · 2015Article
- Positively Charged Oligo[Poly(Ethylene Glycol) Fumarate] Scaffold Implantation Results in a Permissive Lesion Environment after Spinal Cord Injury in Rat.Tissue engineering. Part A · 2015Article
- Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering.Regenerative therapy · 2015Review
- Sponge-mediated lentivirus delivery to acute and chronic spinal cord injuries.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Gene delivery strategies to promote spinal cord repair.Biomarker insights · 2015Review
- 3-D Scaffold Platform for Optimized Non-viral Transfection of Multipotent Stem Cells.Journal of materials chemistry. B · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tissue engineering scaffolds with complex geometries can provide an architecture that directs tissue formation. Drug delivery from these scaffolds to promote regeneration is often challenging due to the complex fabrication processes. Surface-mediated DNA delivery from multiple channel bridges was applied to deliver lipoplexes in vivo to the injured spinal cord. The surface properties of the polymer, DNA deposition with or without drying, and the presence of ECM components were investigated. In vitro studies revealed that fibronectin produced greater expression levels and immobilization efficiencies compared with collagen, laminin, and no coating. In addition, lipoplex incubation on ECM-coated PLG increased expression relative to either of the drying methods. Additionally, the incubation method had more homogeneously distributed lipoplexes and a higher number of transfected cells relative to the dried conditions. Translation to three-dimensional bridges led to high levels of transgene expression in vitro. In vivo, lipoplexes immobilized to the bridge produced transgene expression levels in a rat spinal cord hemisection model that were 2-fold greater than naked plasmid. Additionally, expression with lipoplexes persisted for at least three weeks. Surface-mediated delivery can be applied to scaffolds with complex geometries to promote transgene expression in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.