ArticleBMC genomics2009
Mapping QTL affecting resistance to Marek's disease in an F6 advanced intercross population of commercial layer chickens.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
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- Development of a comprehensive GWAS atlas for chicken breeds.BMC bioinformatics · 2026Article
- Integrated transcriptomic and metabolomic analysis identifies host response mechanisms to oncogenic Marek's disease virus in Wenchang chickens.Veterinary research · 2025Article
- scRNA seq of an F1 cross of Marek's disease resistant and susceptible chickens identifies allele specific expression signatures enriched in transcription modulators.Scientific reports · 2025Article
- Research Note: Phenotypic trends for the multigenerational advanced intercross of the Virginia body weight lines of chickens.Poultry science · 2024Article
- Epigenetic Factor MicroRNAs Likely Mediate Vaccine Protection Efficacy against Lymphomas in Response to Tumor Virus Infection in Chickens through Target Gene Involved Signaling Pathways.Veterinary sciences · 2024Article
- Article
- The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek's Disease Virus Pathogenesis and Tumorigenesis.Frontiers in immunology · 2022Article
- Selection for Favorable Health Traits: A Potential Approach to Cope with Diseases in Farm Animals.Animals : an open access journal from MDPI · 2020Review
- Article
- From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles.Frontiers in immunology · 2020Review
- Genetic assessment of inbred chicken lines indicates genomic signatures of resistance to Marek's disease.Journal of animal science and biotechnology · 2018Article
- Characterization of Copy Number Variation's Potential Role in Marek's Disease.International journal of molecular sciences · 2017Article
- Article
- Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes.Genetics, selection, evolution : GSE · 2016Article
- Fine-mapping QTLs in advanced intercross lines and other outbred populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Dual transcriptomics of virus-host interactions: comparing two Pacific oyster families presenting contrasted susceptibility to ostreid herpesvirus 1.BMC genomics · 2014Article
- Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease.G3 (Bethesda, Md.) · 2013Article
- MHC class I of saltwater crocodiles (Crocodylus porosus): polymorphism and balancing selection.Immunogenetics · 2012Article
- Toward integrative genomics study of genetic resistance to Salmonella and Campylobacter intestinal colonization in fowl.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMarek's disease (MD) is a T-cell lymphoma of chickens caused by the Marek's disease virus (MDV), an oncogenic avian herpesvirus. MD is a major cause of economic loss to the poultry industry and the most serious and persistent infectious disease concern. A full-sib intercross population, consisting of five independent families was generated by crossing and repeated intercrossing of two partially inbred commercial White Leghorn layer lines known to differ in genetic resistance to MD. At the F6 generation, a total of 1615 chicks were produced (98 to 248 per family) and phenotyped for MD resistance measured as survival time in days after challenge with a very virulent plus (vv+) strain of MDV.
resultsQTL affecting MD resistance were identified by selective DNA pooling using a panel of 15 SNPs and 217 microsatellite markers. Since MHC blood type (BT) is known to affect MD resistance, a total of 18 independent pool pairs were constructed according to family x BT combination, with some combinations represented twice for technical reasons. Twenty-one QTL regions (QTLR) affecting post-challenge survival time were identified, distributed among 11 chromosomes (GGA1, 2, 3, 4, 5, 8, 9, 15, 18, 26 and Z), with about two-thirds of the MD resistance alleles derived from the more MD resistant parental line. Eight of the QTLR associated with MD resistance, were previously identified in a backcross (BC) mapping study with the same parental lines. Of these, 7 originated from the more resistant line, and one from the less resistant line.
conclusionThere was considerable evidence suggesting that MD resistance alleles tend to be recessive. The width of the QTLR for these QTL appeared to be reduced about two-fold in the F6 as compared to that found in the previous BC study. These results provide a firm basis for high-resolution linkage disequilibrium mapping and positional cloning of the resistance genes.
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