ArticleBMC cell biology2009
Comparative characterization of mesenchymal stem cells from eGFP transgenic and non-transgenic mice.
Article in BMC cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Potential drawbacks in cell-assisted lipotransfer: A systematic review of existing reports (Review).Molecular medicine reports · 2016Pooled it
- Preconditioning with Rapamycin Improves Therapeutic Potential of Placenta-Derived Mesenchymal Stem Cells in Mouse Model of Hematopoietic Acute Radiation Syndrome.International journal of molecular sciences · 2025Article
- The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis.Nutrients · 2023Review
- DPP4-Truncated CXCL12 Alters CXCR4/ACKR3 Signaling, Osteogenic Cell Differentiation, Migration, and Senescence.ACS pharmacology & translational science · 2023Article
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- Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells.Bone reports · 2020Article
- Functional endoscopy techniques for tracking stem cell fate.Quantitative imaging in medicine and surgery · 2019Review
- Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent.American journal of physiology. Renal physiology · 2018Article
- Therapeutic potential of adipose-derived stem cells and macrophages for ischemic skeletal muscle repair.Regenerative medicine · 2017Article
- Mesenchymal stem cell expression of stromal cell-derived factor-1β augments bone formation in a model of local regenerative therapy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
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- Article
- Adipose derived mesenchymal stem cells efficiently rescue carbon tetrachloride-induced acute liver failure in mouse.TheScientificWorldJournal · 2014Article
- Multipotent stromal cells alleviate inflammation, neuropathology, and symptoms associated with globoid cell leukodystrophy in the twitcher mouse.Stem cells (Dayton, Ohio) · 2013Article
- Adipose-derived stromal cells accelerate wound healing in an organotypic raft culture model.Annals of plastic surgery · 2012Article
- Fetal liver-derived mesenchymal stem cell engraftment after allogeneic in utero transplantation into rabbits.Stem cells and development · 2012Article
- Mesenchymal stem cells as a novel vaccine platform.Frontiers in cellular and infection microbiology · 2012Article
- Effect of intrastriatal mesenchymal stromal cell injection on progression of a murine model of Krabbe disease.Behavioural brain research · 2011Article
- MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells.Stem cell research & therapy · 2011Article
- Mesenchymal lineage stem cells have pronounced anti-inflammatory effects in the twitcher mouse model of Krabbe's disease.Stem cells (Dayton, Ohio) · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipose derived- and bone marrow-derived murine mesenchymal stem cells (mMSCs) may be used to study stem cell properties in an in vivo setting for the purposes of evaluating therapeutic strategies that may have clinical applications in the future. If these cells are to be used for transplantation, the question arises of how to track the administered cells. One solution to this problem is to transplant cells with an easily identifiable genetic marker such as enhanced green fluorescent protein (eGFP). This protein is fluorescent and therefore does not require a chemical substrate for identification and can be visualized in living cells. This study seeks to characterize and compare adipose derived- and bone marrow-derived stem cells from C57Bl/6 mice and eGFP transgenic C57Bl/6 mice.
resultsThe expression of eGFP does not appear to affect the ability to differentiate along adipogenic or osteogenic lineages; however it appears that the tissue of origin can influence differentiation capabilities. The presence of eGFP had no effect on cell surface marker expression, and mMSCs derived from both bone marrow and adipose tissue had similar surface marker profiles. There were no significant differences between transgenic and non-transgenic mMSCs.
conclusionMurine adipose derived and bone marrow derived mesenchymal stem cells from non-transgenic and eGFP transgenic C57Bl/6 mice have very similar characterization profiles. The availability of mesenchymal stem cells stably expressing a genetic reporter has important applications for the advancement of stem cell research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.