ReviewBiochemical Society transactions2009
Amino acid sensing and mTOR regulation: inside or out?
Review in Biochemical Society transactions, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids.The Journal of nutrition · 2011Trial
- Discovery and Profiling of Protein CysteineMolecules (Basel, Switzerland) · 2025Article
- Replacement of Dietary Fishmeal Protein with Degossypolized Cottonseed Protein on Growth Performance, Nonspecific Immune Response, Antioxidant Capacity, and Target of Rapamycin Pathway of Juvenile Large Yellow Croaker (Aquaculture nutrition · 2022Article
- Supplementing with L-Tryptophan Increases Medium Protein and Alters Expression of Genes and Proteins Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells.International journal of molecular sciences · 2021Article
- Differential metabolic sensitivity of insulin-like-response- and TORC1-dependent overgrowth in Drosophila fat cells.Genetics · 2021Article
- Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand.Frontiers in cell and developmental biology · 2021Review
- A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7.Molecular genetics and genomics : MGG · 2019Article
- PATs and SNATs: Amino Acid Sensors in Disguise.Frontiers in pharmacology · 2018Article
- Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.Molecular cancer therapeutics · 2016 · on this mapArticle
- Synthesis, Radiolabeling, and Biological Evaluation of (R)- and (S)-2-Amino-5-[(18)F]fluoro-2-methylpentanoic Acid ((R)-, (S)-[(18)F]FAMPe) as Potential Positron Emission Tomography Tracers for Brain Tumors.Journal of medicinal chemistry · 2015Article
- Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.Amino acids · 2014Article
- Dietary interactions with the bacterial sensing machinery in the intestine: the plant polyphenol case.Frontiers in genetics · 2014Review
- Amino acid transporters in the regulation of human skeletal muscle protein metabolism.Current opinion in clinical nutrition and metabolic care · 2013Review
- Nutrition and the biology of human ageing: bone health and osteoporosis / sarcopenia / immune deficiency.The journal of nutrition, health & aging · 2013Article
- Autophagy is a cell death mechanism in Toxoplasma gondii.Cellular microbiology · 2012Article
- Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.PloS one · 2012Article
- Evolution of the TOR pathway.Journal of molecular evolution · 2011Article
- Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- A glutathione peroxidase, intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. elegans.PloS one · 2011Article
- Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation.Oncogene · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
mTOR (mammalian target of rapamycin) plays a key role in determining how growth factor, nutrient and oxygen levels modulate intracellular events critical for the viability and growth of the cell. This is reflected in the impact of aberrant mTOR signalling on a number of major human diseases and has helped to drive research to understand how TOR (target of rapamycin) is itself regulated. While it is clear that amino acids can affect TOR signalling, how these molecules are sensed by TOR remains controversial, perhaps because cells use different mechanisms as environmental conditions change. Even the question of whether they have an effect inside the cell or at its surface remains unresolved. The present review summarizes current ideas and suggests ways in which some of the models proposed might be unified to produce an amino acid detection system that can adapt to environmental change.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.