Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2009
Use of a lidocaine patch in the management of postsurgical neuropathic pain in patients with cancer: a phase III double-blind crossover study (N01CB).
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy Of Lidocaine Patch In The Management Of Postsurgical Neuropathic Pain In Patients With Cancer: A Phase III Double-Blind, Crossover Study
The PATCH Trial: Effectiveness and Safety of 5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement.Canadian family physician Medecin de famille canadien · 2017Pooled it
- Topical lidocaine for neuropathic pain in adults.The Cochrane database of systematic reviews · 2014Pooled it
- Pharmacological management of chronic neuropathic pain: revised consensus statement from the Canadian Pain Society.Pain research & managementGuideline
- Lidocaine 5 % patches as an effective short-term co-analgesic in cancer pain. Preliminary results.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Trial
- Treatment of neuropathic pain in cancer survivors: a scoping review of pharmacological, exercise, and psychosocial interventions.Acta oncologica (Stockholm, Sweden) · 2026Article
- Topical analgesics for neuropathic pain: an evidence-informed guide for the practicing clinician.Pain medicine (Malden, Mass.) · 2026Review
- Review
- Article
- Topical Lidocaine for Chronic Pain Treatment.Drug design, development and therapy · 2021Review
- Neuropathic Pain and Sickle Cell Disease: a Review of Pharmacologic Management.Current pain and headache reports · 2020Review
- Topical Treatment of Localized Neuropathic Pain in the Elderly.Drugs & aging · 2020Review
- A Comprehensive Algorithm for Management of Neuropathic Pain.Pain medicine (Malden, Mass.) · 2019Review
- Frequent Occurrence of Pain and Prescription Opioid Use for Treatment of Pain Among Women with and at Risk for HIV Infection.AIDS and behavior · 2018Article
- Prognostic significance of baseline fatigue for overall survival: A patient-level meta-analysis of 43 oncology clinical trials with 3915 patients.Trends in cancer research · 2017Article
- The topical 5% lidocaine medicated plaster in localized neuropathic pain: a reappraisal of the clinical evidence.Journal of pain research · 2016Review
- [Current therapy of neuropathic pain].Der Nervenarzt · 2013Review
- Treatment of acute and chronic focal neuropathic pain in cancer patients with lidocaine 5 % patches. A radiation and oncology department experience.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- Can treatment success with 5% lidocaine medicated plaster be predicted in cancer pain with neuropathic components or trigeminal neuropathic pain?Journal of pain research · 2013Article
- Reporting characteristics of cancer pain: a systematic review and quantitative analysis of research publications in palliative care journals.Indian journal of palliative care · 2011Article
- Use of lidocaine patches for neuropathic pain in a comprehensive cancer centre.Pain research & managementArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveCurrent therapies often have limited efficacy and untenable side effects when used to treat persistent incisional pain following cancer-related surgery. Lidocaine patches reduce neuropathic pain from herpes zoster but their benefits for persistent cancer-related postsurgical incisional pain remain unclear. STUDY
designMulticenter, double-blind, randomized, two-period crossover trial. MATERIALS AND
methodsTwenty-eight cancer patients with postsurgical incisional pain were randomly assigned to receive either lidocaine patches followed by placebo patches or the reverse. Each study period lasted 4 weeks. Patches were applied daily upon waking and left in place for a maximum of 18 h. The primary outcome measure, an 11-point pain intensity rating scale, was administered weekly. Secondary outcomes were administered weekly (Brief Pain Inventory-Short Form(BPI-SF), Subject Global Impression of Change) and at the end of each study period (Short Form-Magill Pain Questionnaire, Linear Analogue Self Assessment Scale, Neuropathy Pain Scale, Pain Catastrophizing Scale, Profile of Mood States Short Form).
resultsTwenty-one patients completed the first period and 18 completed their crossover second phase. No significant intergroup differences were detected in pain intensity ratings. Few secondary end points were significantly different when subjects used the lidocaine versus placebo patches. BPI-SF interference scores were lower in patients using the lidocaine patch during the first study period, including several scores that achieved statistical significance, general activity (p = 0.02), work (p = 0.04), and relations with others (p = 0.02).
conclusionLidocaine patch use did not significantly reduce pain intensity ratings or the majority of related secondary end points in cancer patients with persistent incisional pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.