Evidence map›Paper›PMID 19142207›Full record

ArticleEuropean journal of human genetics : EJHG2009

MYO9B polymorphisms in multiple sclerosis.

Anu Kemppinen, Minna Suvela, Pentti J Tienari, Irina Elovaara, Keijo Koivisto, Tuula Pirttilä, Mauri Reunanen, Ilkka Rautakorpi, Jan Hillert, Frida Lundmark and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of human genetics : EJHG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Fixing the GAP: The role of RhoGAPs in cancer.European journal of cell biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 6 countries.

Anu KemppinenDepartment of Molecular Medicine, National Public Health Institute and Institute for Molecular Medicine Finland, FIMM, Helsinki, Finland.
Minna Suvela
Pentti J Tienari
Irina Elovaara
Keijo Koivisto
Tuula Pirttilä
Mauri Reunanen
Ilkka Rautakorpi
Jan Hillert
Frida Lundmark
Annette Oturai
Lars Ryder
Hanne F Harbo
Elisabeth G Celius
Aarno Palotie
Mark Daly
Leena Peltonen
Janna Saarela
University of Helsinki · FICopenhagen University Hospital · DKInstitute for Molecular Medicine Finland · FIOslo University Hospital · NOBroad Institute · USHarvard University · USKarolinska Institutet · SEKarolinska University Hospital · SEKuopio University Hospital · FILapland Central Hospital · FIOulu University Hospital · FISeinäjoki University of Applied Sciences · FITampere University Hospital · FI

Funding

Genetic loci predisposing to multiple sclerosis (MS)R01NS043559 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PELTONEN, LEENA · 2002 to 2005
$984k
NINDS NIH HHS NS 43559NINDS NIH HHS R01 NS043559Wellcome Trust 089061Wellcome Trust 089062
6 · The paper itself

Abstract

Single-nucleotide polymorphisms (SNPs) in the 3' region of myosin IXB (MYO9B) gene have recently been reported to associate with different inflammatory or autoimmune diseases. We monitored for the association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations. First, 18 SNPs including 6 SNPs with previous evidence for association to immune disorders, were tested in 730 Finnish MS families, but no linkage or family-based association was observed. To ensure the power to detect variants with a modest effect size, we further analyzed 10 variants in 899 Finnish cases and 1325 controls, and in a total of 1521 cases and 1476 controls from Denmark, Norway and Sweden, but found no association. Our results thereby do not support a major function of the tested MYO9B variants in MS.

Indexed as

Case-Control StudiesFamilyGenotypeHumansMultiple SclerosisMyosinsPolymorphism, GeneticWhite Peoplemyosin IXBMyosins

Identifiers

PMID19142207
PMCPMC2685895
OpenAlexW2054833096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.