ArticleJournal of vascular research2009
Ubiquitous yet distinct expression of podocalyxin on vascular surfaces in normal and tumor tissues in the rat.
Article in Journal of vascular research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Cerebrospinal fluid and dural accumulation of α-synuclein impairs CNS clearance in Parkinson's disease.The Journal of experimental medicine · 2026Article
- Anatomy and function of the vertebral column lymphatic network in mice.Nature communications · 2019Article
- In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors.Nature medicine · 2014Article
- Overcoming key technological challenges in using mass spectrometry for mapping cell surfaces in tissues.Molecular & cellular proteomics : MCP · 2011Review
- Identification and expression profiling of blood-brain barrier membrane proteins.Journal of neurochemistry · 2010Article
- Lung vascular targeting using antibody to aminopeptidase P: CT-SPECT imaging, biodistribution and pharmacokinetic analysis.Journal of vascular research · 2010Article
- Targeting and imaging signature caveolar molecules in lungs.Proceedings of the American Thoracic Society · 2009Article
- Immunotargeting and cloning of two CD34 variants exhibiting restricted expression in adult rat endothelia in vivo.American journal of physiology. Lung cellular and molecular physiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND/
aimsThe vasculature has become an important target in the development of therapies for increasing numbers of human diseases, yet there are few reliable markers available to identify the endothelium in rodent models. We have characterized the expression, subcellular localization and accessibility of the rat pan-endothelial marker podocalyxin (podxl) using a newly developed monoclonal antibody (mAb), G278.
methodspodxl expression and accessibility to binding by G278 were determined in the rat by a variety of experimental approaches.
resultsmAb G278 reliably immunostained blood vessels of all types and of every size in fresh-frozen, fixed-frozen and paraffin-embedded sections of all tissues, but did not stain lymphatic vessels. Western blotting, in vivo imaging and biodistribution analyses demonstrated that the highest levels of endothelial podxl were found in the lung and heart. We also determined that podxl is not enriched in caveolae and that its expression can be modulated in the tumor microenvironment.
conclusionOur study shows that podxl is a better identifier of rat endothelia than are some of the more commonly used markers and that mAb G278 is a robust antibody for use not only in identifying rat blood vessels but also as a tool to elucidate podxl function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.