ArticleNeuroendocrinology2009
Daily changes in GT1-7 cell sensitivity to GnRH secretagogues that trigger ovulation.
Article in Neuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Mistimed restricted feeding disrupts circadian rhythms of male mating behavior and female preovulatory LH surges in mice.Hormones and behavior · 2022Article
- Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge.Endocrinology · 2022Review
- Neuroendocrine mechanisms underlying estrogen positive feedback and the LH surge.Frontiers in neuroscience · 2022Review
- Circadian Rhythms Within the Female HPG Axis: From Physiology to Etiology.Endocrinology · 2021Review
- Vasopressinergic Activity of the Suprachiasmatic Nucleus and mRNA Expression of Clock Genes in the Hypothalamus-Pituitary-Gonadal Axis in Female Aging.Frontiers in endocrinology · 2021Article
- Clock control of mammalian reproductive cycles: Looking beyond the pre-ovulatory surge of gonadotropins.Reviews in endocrine & metabolic disorders · 2020Review
- Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis.Molecular and cellular endocrinology · 2020Review
- Circadian Function in Multiple Cell Types Is Necessary for Proper Timing of the Preovulatory LH Surge.Journal of biological rhythms · 2019Article
- Time-of-day-dependent sensitivity of the reproductive axis to RFamide-related peptide-3 inhibition in female Syrian hamsters.Journal of neuroendocrinology · 2019Article
- Molecular Mechanisms of Gonadotropin-Inhibitory Hormone (GnIH) Actions in Target Cells and Regulation of GnIH Expression.Frontiers in endocrinology · 2019Review
- Circadian Control of Neuroendocrine Function: Implications for Health and Disease.Current opinion in physiology · 2018Article
- Unilaterally blocking the muscarinic receptors in the suprachiasmatic nucleus in proestrus rats prevents pre-ovulatory LH secretion and ovulation.Reproductive biology and endocrinology : RB&E · 2016Article
- A "Timed" Kiss Is Essential for Reproduction: Lessons from Mammalian Studies.Frontiers in endocrinology · 2016Review
- Circadian Control of the Female Reproductive Axis Through Gated Responsiveness of the RFRP-3 System to VIP Signaling.Endocrinology · 2015Article
- Circadian Tick-Talking Across the Neuroendocrine System and Suprachiasmatic Nuclei Circuits: The Enigmatic Communication Between the Molecular and Electrical Membrane Clocks.Journal of neuroendocrinology · 2015Review
- A Multi-Oscillatory Circadian System Times Female Reproduction.Frontiers in endocrinology · 2015Review
- Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells.Molecular and cellular endocrinology · 2013Article
- Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Circadian regulation of kisspeptin in female reproductive functioning.Advances in experimental medicine and biology · 2013Review
- Clocks on top: the role of the circadian clock in the hypothalamic and pituitary regulation of endocrine physiology.Molecular and cellular endocrinology · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythms in behavior and physiology are orchestrated by a master biological clock located in the suprachiasmatic nucleus (SCN). Circadian oscillations are a cellular property, with 'clock' genes and their protein products forming transcription-translation feedback loops that maintain 24-hour rhythmicity. Although the expression of clock genes is thought to be ubiquitous, the function of local, extra-SCN timing mechanisms remains elusive. We hypothesized that extra-SCN clock genes control local temporal sensitivity to upstream modulatory signals, allowing system-specific processes to be carried out during individual, optimal times of day. To test this possibility, we examined changes in the sensitivity of immortalized GnRH neurons, GT1-7 cells, to timed stimulation by two key neuropeptides thought to trigger ovulation on the afternoon of proestrus, kisspeptin and vasoactive intestinal polypeptide (VIP). We noted a prominent daily rhythm of clock gene expression in this cell line. GT1-7 cells also exhibited daily changes in cellular peptide expression and GnRH secretion in response to kisspeptin and VIP stimulation. These responses occurred without changes in GnRH transcription. These findings are consistent with the notion that GnRH cells are capable of intrinsic circadian cycles that may be fundamental for coordinating daily changes in sensitivity to signals impacting the reproductive axis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.