ArticleThe American journal of tropical medicine and hygiene2009
Hyponatremia in severe malaria: evidence for an appropriate anti-diuretic hormone response to hypovolemia.
Article in The American journal of tropical medicine and hygiene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis.PloS one · 2013Pooled it
- KDIGO stage 3 acute kidney injury in children with severe Plasmodium falciparum malaria including blackwater fever: a case series from a resource-limited setting in Southwest Ethiopia.BMC nephrology · 2026Article
- Evaluation of serum electrolytes and kidney function among untreated malaria (Plasmodium falciparum) patients in health centers, Konso zone, South Ethiopia.Tropical diseases, travel medicine and vaccines · 2025Article
- Prevalence and factors associated with cerebral malaria among children aged 6 to 59 months with severe malaria in Western Uganda: a hospital-based cross-sectional study.BMC pediatrics · 2024Article
- Severe orthostatic hypotension in otherwise uncomplicated Plasmodium vivax infection.Malaria journal · 2021Article
- Reduced Cardiac Index Reserve and Hypovolemia in Severe Falciparum Malaria.The Journal of infectious diseases · 2020Article
- Hyponatraemia and Syndrome of Inappropriate Antidiuretic Hormone Secretion in Non-azotaemic Dogs with Babesiosis Associated with Decreased Arterial Blood Pressure.Journal of veterinary research · 2019Article
- HIV infection has a profound effect on hematological factors but not on electrolyte profile of Malawian adults presenting with uncomplicated malaria and severe malaria.Journal of blood medicine · 2018Article
- Sodium Disturbances in Children Admitted to a Kenyan Hospital: Magnitude, Outcome and Associated Factors.PloS one · 2016Article
- The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs.International journal for parasitology. Drugs and drug resistance · 2015Review
- Electrolyte Disturbance and the Type of Malarial Infection.Iranian journal of public health · 2015Article
- Malaria and hypertension. Another co-evolutionary adaptation?Frontiers in cellular and infection microbiology · 2014Review
- Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response.Clinical proteomics · 2013Article
- Hyponatraemia in imported malaria: the pathophysiological role of vasopressin.Malaria journal · 2012Article
- Copeptin does not accurately predict disease severity in imported malaria.Malaria journal · 2012Article
- Outcome and prognostic factors of malaria-associated acute kidney injury requiring hemodialysis: A single center experience.Indian journal of nephrology · 2012Article
- Atypical manifestations of malaria.Research and reports in tropical medicine · 2011Review
- Hyponatraemia in imported malaria is common and associated with disease severity.Malaria journal · 2010Article
- CMCH and MORU: a Highly Successful Collaboration.Journal of Chittagong Medical College Teachers' Association · 2010Article
- A simple score to predict the outcome of severe malaria in adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although hyponatremia occurs in most patients with severe malaria, its pathogenesis, prognostic significance, and optimal management have not been established. Clinical and biochemical data were prospectively collected from 171 consecutive Bangladeshi adults with severe malaria. On admission, 57% of patients were hyponatremic. Plasma sodium and Glasgow Coma Score were inversely related (r(s) = -0.36, P < 0.0001). Plasma antidiuretic hormone concentrations were similar in hyponatremic and normonatremic patients (median, range: 6.1, 2.3-85.3 versus 32.7, 3.0-56.4 pmol/L; P = 0.19). Mortality was lower in hyponatremic than normonatremic patients (31.6% versus 51.4%; odds ratio [95% confidence interval]: 0.44 [0.23-0.82]; P = 0.01 by univariate analysis). Plasma sodium normalized with crystalloid rehydration from (median, range) 127 (123-140) mmol/L on admission to 136 (128-149) mmol/L at 24 hours (P = 0.01). Hyponatremia in adults with severe malaria is common and associated with preserved consciousness and decreased mortality. It likely reflects continued oral hypotonic fluid intake in the setting of hypovolemia and requires no therapy beyond rehydration.
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