ArticleThe Plant cell2009
Formation of nuclear bodies of Arabidopsis CRY2 in response to blue light is associated with its blue light-dependent degradation.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 144 citations in OpenAlex.
- Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Engineering bi-directional chemically-modulated synthetic condensates for cellular control.Nature communications · 2025Article
- The CRY1-COP1-HY5 axis mediates blue-light regulation of Arabidopsis thermotolerance.Plant communications · 2025Article
- The CRY1-HsF predicted interaction interface serves as a molecular platform for bioengineering or selecting modulating mutants.Frontiers in plant science · 2025Article
- Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization.Journal of molecular biology · 2024Article
- Blue light perceiving CRY proteins: protecting plants from DNA damage.Plant cell reports · 2024Article
- Light signaling in plants-a selective history.Plant physiology · 2024Review
- Exocytic plasma membrane flows remodel endoplasmic reticulum-plasma membrane tethering for septin collar assembly.Science advances · 2024Article
- Development of an optogenetics tool, Opto-RANK, for control of osteoclast differentiation using blue light.Scientific reports · 2024Article
- Dual-transgenic BiFC vector systems for protein-protein interaction analysis in plants.Frontiers in genetics · 2024Article
- 'Seeing' the electromagnetic spectrum: spotlight on the cryptochrome photocycle.Frontiers in plant science · 2024Review
- A structural decryption of cryptochromes.Frontiers in chemistry · 2024Review
- Photoexcited cryptochromes interact with ADA2b and SMC5 to promote the repair of DNA double-strand breaks in Arabidopsis.Nature plants · 2023Article
- Cryptochromes suppress leaf senescence in response to blue light in Arabidopsis.Plant physiology · 2023Article
- Phytochrome B photobodies are comprised of phytochrome B and its primary and secondary interacting proteins.Nature communications · 2023Article
- Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9.Nature communications · 2022Article
- Arabidopsis cryptochrome 2 forms photobodies with TCP22 under blue light and regulates the circadian clock.Nature communications · 2022Article
- The Function and Photoregulatory Mechanisms of Cryptochromes From Moso Bamboo (Frontiers in plant science · 2022Article
- Functions of COP1/SPA E3 Ubiquitin Ligase Mediated by MpCRY in the LiverwortInternational journal of molecular sciences · 2021Article
- Light-Response Bric-A-Brack/Tramtrack/Broad proteins mediate cryptochrome 2 degradation in response to low ambient temperature.The Plant cell · 2021Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Arabidopsis thaliana cryptochrome 2 (CRY2) mediates photoperiodic promotion of floral initiation and blue light inhibition of hypocotyl elongation. It has been hypothesized that photoexcitation derepresses CRY2 by disengaging its C-terminal domain from the N-terminal PHR domain. To test this hypothesis, we analyzed activities of CRY2 fused to green fluorescent protein (GFP) at either the N terminus (GFP-CRY2) or the C terminus (CRY2-GFP). While GFP-CRY2 exerts light-dependent biochemical and physiological activities similar to those of the endogenous CRY2, CRY2-GFP showed constitutive biochemical and physiological activities. CRY2-GFP is constitutively phosphorylated, it promotes deetiolation in both dark and light, and it activates floral initiation in both long-day and short-day photoperiods. These results are consistent with the hypothesis that photoexcited CRY2 disengages its C-terminal domain from the PHR domain to become active. Surprisingly, we found that CRY2-GFP, but not GFP-CRY2, formed distinct nuclear bodies in response to blue light. Compared with GFP-CRY2 or the endogenous CRY2, CRY2-GFP degradation was significantly retarded in response to blue light, suggesting that the nuclear bodies may result from accumulation of photoexcited CRY2-GFP waiting to be degraded. Consistent with this interpretation, we showed that both GFP-CRY2 and endogenous CRY2 formed nuclear bodies in the presence of the 26S-proteasome inhibitors that block blue light-dependent CRY2 degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.