ArticleProceedings of the National Academy of Sciences of the United States of America2009
Tetrapyrrole signal as a cell-cycle coordinator from organelle to nuclear DNA replication in plant cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 117 citations in OpenAlex.
- Article
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- The Role of Tetrapyrrole- and GUN1-Dependent Signaling on Chloroplast Biogenesis.Plants (Basel, Switzerland) · 2021Review
- Changes in plastid biogenesis leading to the formation of albino regenerants in barley microspore culture.BMC plant biology · 2021Article
- Albino Plant Formation in Androgenic Cultures: An Old Problem and New Facts.Methods in molecular biology (Clifton, N.J.) · 2021Review
- An Insight Into the Mechanism of Plant Organelle Genome Maintenance and Implications of Organelle Genome in Crop Improvement: An Update.Frontiers in cell and developmental biology · 2021Review
- FATTY ACID DESATURASE5 Is Required to Induce Autoimmune Responses in Gigantic Chloroplast Mutants of Arabidopsis.The Plant cell · 2020Article
- Evolutionary significance of the ring-like plastid nucleus in the primitive red alga Cyanidioschyzon merolae as revealed by drying.Protoplasma · 2020Article
- Proteomic analysis of haem-binding protein fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Integration of aPlant direct · 2019Article
- Insights into the Mechanisms of Chloroplast Division.International journal of molecular sciences · 2018Review
- The Molecular Machinery of Chloroplast Division.Plant physiology · 2018Review
- Inhibitor-induced oxidation of the nucleus and cytosol inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Plastid-nucleus communication involves calcium-modulated MAPK signalling.Nature communications · 2016Article
- Surfing the vegetal pole in a small population: extracellular vertical transmission of an 'intracellular' deep-sea clam symbiont.Royal Society open science · 2016Article
- Tetrapyrrole Signaling in Plants.Frontiers in plant science · 2016Review
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6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic cells arose from an ancient endosymbiotic association of prokaryotes, with plant cells harboring 3 genomes as the remnants of such evolution. In plant cells, plastid and mitochondrial DNA replication [organelle DNA replication (ODR)] occurs in advance of the subsequent cell cycles composed of nuclear DNA replication (NDR) and cell division. However, the mechanism by which replication of these genomes with different origins is coordinated is largely unknown. Here, we show that NDR is regulated by a tetrapyrrole signal in plant cells, which has been suggested as an organelle-to-nucleus retrograde signal. In synchronized cultures of the primitive red alga Cyanidioschyzon merolae, specific inhibition of A-type cyclin-dependent kinase (CDKA) prevented NDR but not ODR after onset of the cell cycle. In contrast, inhibition of ODR by nalidixic acid also resulted in inhibition of NDR, indicating a strict dependence of NDR on ODR. The requirement of ODR for NDR was bypassed by addition of the tetrapyrrole intermediates protoporphyrin IX (ProtoIX) or Mg-ProtoIX, both of which activated CDKA without inducing ODR. This scheme was also observed in cultured tobacco cells (BY-2), where inhibition of ODR by nalidixic acid prevented CDKA activation and NDR, and these inhibitions were circumvented by Mg-ProtoIX without inducing ODR. We thus show that tetrapyrrole-mediated organelle-nucleus replicational coupling is an evolutionary conserved process among plant cells.
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