SynthesisEuropean heart journal2009
Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation.
Synthesis in European heart journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01719367 (Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation), which is not on this map. Cited by 91 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation
Who cites it
91 citing papers in PubMed, 5 syntheses or guidelines pooled it, 219 citations in OpenAlex.
- Chromosome 4q25 Variants rs2200733, rs10033464, and rs1906591 Contribute to Ischemic Stroke Risk.Molecular neurobiology · 2016Pooled it
- Genetic polymorphisms for estimating risk of atrial fibrillation: a literature-based meta-analysis.Journal of internal medicine · 2012Pooled it
- Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.Nature genetics · 2012Pooled it
- Meta-analysis identifies six new susceptibility loci for atrial fibrillation.Nature genetics · 2012Pooled it
- Lack of replication in polymorphisms reported to be associated with atrial fibrillation.Heart rhythm · 2011Pooled it
- The cardiac conduction system: development, function and therapeutic targets.Nature reviews. Cardiology · 2026Review
- Single-Nucleotide Polymorphisms,International journal of molecular sciences · 2025Review
- Oxidative Stress Causes Mitochondrial and Electrophysiologic Dysfunction to Promote Atrial Fibrillation inCirculation. Arrhythmia and electrophysiology · 2025Article
- [Cardiogenetics in Germany- a view and review].Herzschrittmachertherapie & Elektrophysiologie · 2024Review
- The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency.Journal of molecular and cellular cardiology · 2023Article
- PITX2 induction leads to impaired cardiomyocyte function in arrhythmogenic cardiomyopathy.Stem cell reports · 2023Article
- Advances of Liquid Biopsy for Diagnosis of Atrial Fibrillation and Its Recurrence After Ablation in Clinical Application.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Genetic risk factors for postoperative atrial fibrillation-a nationwide genome-wide association study (GWAS).Frontiers in cardiovascular medicine · 2023Article
- Late arrhythmia recurrence after atrial fibrillation ablation: incidence, mechanisms and clinical implications.Herzschrittmachertherapie & Elektrophysiologie · 2022Review
- Atrial Cardiopathy and Cryptogenic Stroke.Frontiers in neurology · 2022Review
- Piezo1 Participated in Decreased L-Type Calcium Current Induced by High Hydrostatic PressureFrontiers in cardiovascular medicine · 2022Article
- Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Atrial Fibrillation Genomics: Discovery and Translation.Current cardiology reports · 2021Review
- Genetics of atrial fibrillation-practical applications for clinical management: if not now, when and how?Cardiovascular research · 2021Review
- Genetics and Epigenetics of Atrial Fibrillation.International journal of molecular sciences · 2020Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 12 institutions in 3 countries.
Funding
Abstract
aimsA recent genome-wide association study identified a haplotype block on chromosome 4q25 associated with atrial fibrillation (AF). We sought to replicate this association in four independent cohorts. METHODS AND
resultsThe Framingham Heart Study and Rotterdam Study are community-based longitudinal studies. The Vanderbilt AF Registry and German AF Network (AFNet) are case-control studies. Participants with AF (n = 3508) were more likely to be male and were older than referent participants (n = 12 173; Framingham 82 +/- 10 vs. 71 +/- 13 years; Rotterdam 73 +/- 8 vs. 69 +/- 9 years; Vanderbilt 54 +/- 14 vs. 57 +/- 14 years; AFNet 62 +/- 12 vs. 49 +/- 14 years). Single nucleotide polymorphism (SNP) rs2200733 was associated with AF in all four cohorts, with odds ratios (ORs) ranging from 1.37 in Rotterdam [95% confidence interval (CI) 1.18-1.59; P = 3.1 x 10(-5)] to 2.52 in AFNet (95% CI 2.22-2.8; P = 1.8 x 10(-49)). There also was a significant association between AF and rs10033464 in Framingham (OR 1.34; 95% CI 1.03-1.75; P = 0.031) and AFNet (OR 1.30; 95% CI 1.13-1.51; P = 0.0002), but not Vanderbilt (OR 1.16; 95% CI 0.86-1.56; P = 0.33). A meta-analysis of the current and prior AF studies revealed an OR of 1.90 (95% CI 1.60-2.26; P = 3.3 x 10(-13)) for rs2200733 and of 1.36 (95% CI 1.26-1.47; P = 6.7 x 10(-15)) for rs10033464.
conclusionThe non-coding SNPs rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent. These results confirm the significant relations between AF and intergenic variants on chromosome 4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.