ArticleGenes & development2008
Protein phosphatase PP1 is required for normal DNA methylation in Neurospora.
Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes.Frontiers in immunology · 2025Article
- H3T11 phosphorylation by CKII is required for heterochromatin formation in Neurospora.Nucleic acids research · 2024Article
- Article
- Repo-Man/PP1 regulates heterochromatin formation in interphase.Nature communications · 2017Article
- Dual chromatin recognition by the histone deacetylase complex HCHC is required for proper DNA methylation in Neurospora crassa.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Loss of HP1 causes depletion of H3K27me3 from facultative heterochromatin and gain of H3K27me2 at constitutive heterochromatin.Genome research · 2016Article
- Epigenetics of Epileptogenesis-Evoked Upregulation of Matrix Metalloproteinase-9 in Hippocampus.PloS one · 2016Article
- Neurospora importin α is required for normal heterochromatic formation and DNA methylation.PLoS genetics · 2015Article
- Transcription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II.Molecular and cellular biology · 2013Article
- Substitutions in the amino-terminal tail of neurospora histone H3 have varied effects on DNA methylation.PLoS genetics · 2011Article
- Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit.Developmental cell · 2011Article
- Introduction--Epiphanies in epigenetics.Progress in molecular biology and translational science · 2011Article
- Regulation of secondary metabolism by chromatin structure and epigenetic codes.Fungal genetics and biology : FG & B · 2011Review
- H2B- and H3-specific histone deacetylases are required for DNA methylation in Neurospora crassa.Genetics · 2010Article
- Mapping of lysine methylation and acetylation in core histones of Neurospora crassa.Biochemistry · 2010Article
- Extensive and varied modifications in histone H2B of wild-type and histone deacetylase 1 mutant Neurospora crassa.Biochemistry · 2010Article
- Identification of DIM-7, a protein required to target the DIM-5 H3 methyltransferase to chromatin.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Epigenome manipulation as a pathway to new natural product scaffolds and their congeners.Natural product reports · 2010Review
- Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase.The Journal of cell biology · 2009Article
- Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases.Endocrine reviews · 2009Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Covalent modifications of histones integrate intracellular and extracellular cues to regulate the genome. H3 Lys 9 methylation (H3K9me) can direct heterochromatin formation and DNA methylation, while phosphorylation of H3 Ser 10 (H3S10p) drives gene activation and chromosome condensation. To examine the relationship between H3S10p, H3K9me, and DNA methylation in Neurospora crassa, we built and tested mutants of the putative H3S10 phosphatase, PP1. A PP1-impaired mutant showed increased H3S10p and selective reduction of methylation of H3K9 and DNA. Similarly, amino acid substitutions of H3S10 abolished methylation of H3K9 and DNA. Thus, H3S10 dephosphorylation by PP1 is required for DNA methylation of some loci.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.