SynthesisProceedings. Biological sciences2009
Mode of transmission and the evolution of arbovirus virulence in mosquito vectors.
Synthesis in Proceedings. Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed, 130 citations in OpenAlex.
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- Highly Conserved Core Residues Define Old-World Alphaviruses and Trace Early Evolutionary Divergence.Journal of molecular evolution · 2026Article
- Prolonged exposure to heat enhances mosquito tolerance to viral infection.Communications biology · 2025Article
- Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product?Journal of medical entomology · 2025Review
- Virulence Evolution via Pleiotropy in Vector-Borne Plant Pathogens.Ecology and evolution · 2024Article
- Evaluation of Aedes aegypti control intervention with pyriproxyfen by lcWGS in Manacapuru, Amazonas, Brazil.PLoS neglected tropical diseases · 2024Article
- Peri-domestic entomological surveillance using private traps allows detection of dengue virus inEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Effects of Arboviral Infections on Transposable Element Transcript Levels in Aedes aegypti.Genome biology and evolution · 2024Article
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- No detectable fitness cost of infection by cell-fusing agent virus inRoyal Society open science · 2024Article
- A Brief History of the Discovery of RNA-Mediated Antiviral Immune Defenses in Vector Mosquitos.Microbiology and molecular biology reviews : MMBR · 2023Review
- Developing Wolbachia-based disease interventions for an extreme environment.PLoS pathogens · 2023Article
- Evolutionary consequences of vector-borne transmission: how using vectors shapes host, vector and pathogen evolution.Parasitology · 2022Review
- The vectoring competence of the miteFrontiers in insect science · 2022Article
- Profile of Small RNAs, vDNA Forms and Viral Integrations in Late Chikungunya Virus Infection ofViruses · 2021Article
- Inhibition of defensin A and cecropin A responses to dengue virus 1 infection in Aedes aegypti.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Transcriptome comparison of dengue-susceptible and -resistant field derived strains of Colombian Aedes aegypti using RNA-sequencing.Memorias do Instituto Oswaldo Cruz · 2021Article
- Effect of Oral Infection of Mayaro Virus on Fitness Correlates and Expression of Immune Related Genes inViruses · 2020Article
- Transmission modes affect the population structure of potato virus Y in potato.PLoS pathogens · 2020Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The traditional assumption that vector-borne pathogens should evolve towards a benign relationship with their arthropod vectors has been challenged on theoretical grounds and empirical evidence. However, in the case of arboviruses (arthropod-borne viruses), although a number of investigators have reported experimental evidence for virus-induced vector mortality, others have failed to detect any significant impact. Whether this variation in the observed level of arbovirus virulence depends on biological traits or experimental design is unclear. Here, we perform a meta-analysis of studies across a range of mosquito-virus systems to show that, overall, arboviruses do reduce the survival of their mosquito vectors, but that the magnitude of the effect depends on the vector/virus taxonomic groups and the mode of virus transmission. Alphaviruses were associated with highest virulence levels in mosquitoes. Horizontal transmission (intrathoracic inoculation or oral infection) was correlated with significant virus-induced mortality, whereas a lack of adverse effect was found for Aedes mosquitoes infected transovarially by bunyaviruses-a group of viruses characterized by high natural rates of vertical transmission in their enzootic vectors. Our findings are consistent with the general prediction that vertically transmitted pathogens should be less virulent than those transmitted horizontally. We conclude that varying degrees of virulence observed among vector-virus systems probably reflect different selective pressures imposed on arboviruses that are primarily transmitted horizontally versus vertically.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.