ArticleStructure (London, England : 1993)2009
ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.
Article in Structure (London, England : 1993), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Intra-strain genetic heterogeneity in Toxoplasma gondii ME49: Oxford Nanopore long-read sequencing reveals copy number variation in the ROP8-ROP2A locus.BMC genomics · 2025Article
- Vaccination with a DNA vaccine cocktail encoding TgROP2, TgROP5, TgROP9, TgROP16, TgROP17, and TgROP18 confers limited protection against Toxoplasma gondii in BALB/c mice.Parasitology research · 2024Article
- REVIEW OF DNA VACCINE APPROACHES AGAINST THE PARASITE TOXOPLASMA GONDII.The Journal of parasitology · 2021Review
- Protein kinases in Toxoplasma gondii.International journal for parasitology · 2021Review
- Overview of PoultryFrontiers in veterinary science · 2020Review
- Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane inmSphere · 2019Article
- Prospects for pharmacological targeting of pseudokinases.Nature reviews. Drug discovery · 2019Review
- Tracing the origin and evolution of pseudokinases across the tree of life.Science signaling · 2019Article
- Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association.Nature communications · 2017Article
- Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division.PLoS pathogens · 2017Article
- STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.Structure (London, England : 1993) · 2017Article
- Nucleotide-binding mechanisms in pseudokinases.Bioscience reports · 2015Review
- Isolation and Proteomic Analysis of Rhoptry-Enriched Fractions from Cryptosporidium parvum.Iranian journal of public health · 2015Article
- Neospora caninum Recruits Host Cell Structures to Its Parasitophorous Vacuole and Salvages Lipids from Organelles.Eukaryotic cell · 2015Article
- The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases.The Journal of biological chemistry · 2014Article
- Electrophoretic Patterns of Toxoplasma gondii Excreted/Secreted Antigens and Their Role in Induction of the Humoral Immune Response.Jundishapur journal of microbiology · 2014Article
- A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.The Biochemical journal · 2014Article
- Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.PloS one · 2014Article
- Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence.The Journal of biological chemistry · 2013Article
- Receptor tyrosine kinases with intracellular pseudokinase domains.Biochemical Society transactions · 2013Review
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ROP2 protein and its paralogs are important virulence factors secreted into the host cell by the parasite Toxoplasma gondii. Here we describe the crystal structure of a large and soluble domain of mature ROP2, representative of the ROP2-like protein family. This is a structure of a protein-kinase fold that is devoid of catalytic residues and does not bind ATP. Various structural extensions constitute a signature of this protein family and act to maintain the protein kinase in an open conformation. Our ROP2 structure rules out a previous structural model of attachment of ROP2-like proteins to the parasitophorous vacuole membrane. We propose an alternative mode of membrane attachment implicating basic and amphiphatic helices present in the flexible N terminus of ROP2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.